多发性硬化患者认知障碍分析  

Analysis of cognitive impairment of multiple sclerosis patients

作　　者：李莉莉[1] 张星虎[2] 

机构地区：[1]北京市垂杨柳医院神经内科,北京100022 [2]首都医科大学附属北京天坛医院神经内科,北京100050

出　　处：《郑州大学学报（医学版）》2011年第3期442-445,共4页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:对多发性硬化(MS)患者认知状况、神经电生理及影像学资料进行综合评价。方法:对28例复发缓解型MS患者进行神经心理评价(韦氏成人或儿童智力量表)、神经功能缺损状况评价(EDSS)和生活质量评价(ADL和IADL),以及事件相关电位检查、MRI检查。结果:71.4%(20/28)的MS患者存在认知障碍,其中智力缺损者占60.7%(17/28),临床记忆功能障碍者占64.3%(18/28)。MRI病灶等级评分、P300潜伏期及受教育时间与认知状况有关(P<0.05)。激素应用对患者认知状况无影响(P>0.05)。结论:MS患者有较高认知功能损害发生率,MRI病灶等级评分与P300检查可能是评价认知功能的有效方法。Aim： To evaluate the cognitive impairment of patients with multiple sclerosis（MS）.Methods：Twenty-eight patients with remitting-relapsing MS were recruited.All of them underwent P300 test,MRI scan,and Wechsler Intelligence Tests,Clinical Memory Scale,HAMD,HAMA,EDSS,ADL and IADL were used to assess the patients.Results：71.4% of MS patients had cognitive disorder,and 60.7% intelligence and 64.3% memory ability were abnormal.Education time,MRI lesion grade score,and P300 latency were related to cognitive function of MS patients （P0.05）.Methylprednisolone （oral or infusion） therapy had no significant influence on cognitive impairment（P0.05）.Conclusion：A high incidence of cognitive impairment is in MS patients,P300 latency and MRI may be effective tools to evaluate cognitive function.

关 键 词：多发性硬化 认知障碍 事件相关电位 

分 类 号：R744.5[医药卫生—神经病学与精神病学]