Collective mechanism of molecular motors and a dynamic mechanical model for sarcomere  

作　　者：YIN YueHong GUO Zhao 

机构地区：[1]State Key Laboratory of Mechanism System and Vibration, Institute of Robotics, Shanghai Jiao Tong University, Shanghai 200240, China

出　　处：《Science China(Technological Sciences)》2011年第8期2130-2137,共8页中国科学（技术科学英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant No. 61075101/60643002);the Research Fund of State Key Laboratory of MSV, China (Grant No. MSV-2010-1);the National High-Tech Research and Development Program of China (Grant No. 2006AA04Z240);the Shanghai Dawn Program (Grant No. 07SG14);the Medical and Technology Intercrossing Research Foundation of Shanghai Jiao Tong University (Grant No. YG2010ZD101)

摘　　要：A non-equilibrium statistical method is used to study the collective characteristics of myosin II motors in a sarcomere during its contraction. By means of Fokker-Planck equation of molecular motors, we present a dynamic mechanical model for the sarcomere in skeletal muscle. This model has been solved with a numerical algorithm based on experimental chemical transition rates. The influences of ATP concentration and load on probability density, contraction velocity and maximum active force are discussed respectively. It is shown that contraction velocity and maximum isometric active force increase with the increasing ATP concentration and become constant when the ATP concentration reaches equilibrium saturation. Contraction velocity reduces gradually as the load force increases. We also find that active force begins to increase then decrease with the increasing length of sarcomere, and has a maximum value at the optimal length that all myosin motors can attach to actin filament. Our results are in good agreement with the Hill muscle model.

关 键 词：molecular motor myosin II actin filament SARCOMERE collective characteristics Fokker-Planck equation muscle force model 

分 类 号：O212[理学—概率论与数理统计] V351.11[理学—数学]