SARCOMERE

作品数：10被引量：32H指数：4
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相关领域：医药卫生更多>>
相关作者：邱建华蔡玉梅李少青王宪龙王元虎更多>>
相关机构：山东农业大学更多>>
相关期刊：《Journal of Biomedical Research》《Journal of Sport and Health Science》《Science China(Technological Sciences)》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金更多>>
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Commentary on“Multiscale hamstring muscle adaptations following 9 weeks of eccentric training”
《Journal of Sport and Health Science》2025年第1期67-68,共2页Markus Tilp 
The maximal force a muscle can exert depends on its length,which has been explained by the sliding filament theory on the sarcomere level.1 A longer muscle can act over a greater range of motion and has more sarcomere...
关键词：muscle length sliding filament theory sarcomere level force production multiscale hamstring muscle adaptations contraction velocity 
In vivo proximity proteomics uncovers palmdelphin(PALMD)as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury
《Acta Pharmacologica Sinica》2024年第12期2540-2552,共13页Cong-ting Guo Blake DJardin Jun-sen Lin Rachelle LAmbroise Ze Wang Lu-zi Yang Neil Mazumdar Fu-jian Lu Qing Ma Yang-po Cao Can-zhao Liu Kai-long Li Xu-jie Liu Feng Lan Ming-ming Zhao Han Xiao Er-dan Dong William T.Pu Yu-xuan Guo 
funded by the National Key R&D Program of China(2022YFA1104800);the National Natural Science Foundation of China(82222006);the Beijing Nova Program(20220484205)and Beijing Natural Science Foundation(7232094);supported by National Institute of Health(R01HL146634 and R01HL163937);supported by the Natural Science Foundation of China(82070235 and 92168113);the CAMs Innovation Fund for Medical Sciences(2021-12M-5-003);Haihe Laboratory of Cell Ecosystem Innovation Fund(HH22KYZX0047);supported by the National Natural Science Foundation of China(82170231);Guangdong Basic and Applied Basic Research Foundation(2023B1515020103).
Z-discs are core ultrastructural organizers of cardiomyocytes that modulate many facets of cardiac pathogenesis.Yet a comprehensive proteomic atlas of Z-disc-associated components remain incomplete.Here,we established...
关键词：proximity proteomics sarcomere Z-disc isoproterenol induced cardiac injury palmdelphin 
Biceps femoris long head sarcomere and fascicle length adaptations after 3 weeks of eccentric exercise training
《Journal of Sport and Health Science》2022年第1期43-49,共7页Patricio A.Pincheira Melissa A.Boswell Martino V.Franchi Scott L.Delp Glen A.Lichtwark 
partially funded by a Company of Biologists Travelling Fellowship;partially subsidized by a grant funded by the Australian Research Council(Linkage program)in partnership with the Australian Sports Commission(LP140100260)。
Background:Eccentric exercise increases muscle fascicle lengths;however,the mechanisms behind this adaptation are still unknown.This study aimed to determine whether biceps femoris long head(BFlh)fascicle length incre...
关键词：HAMSTRINGS Nordic hamstring exercise Sarcomerogenesis 
Smyd1 is essential for myosin expression and sarcomere organization in craniofacial,extraocular,and cardiac muscles被引量：2
《Journal of Genetics and Genomics》2021年第3期208-218,共11页Shuang Jiao Rui Xu Shaojun Du 
supported by funding from the U.S.National Institute of Health(NIH)National Institute of Arthritis and Musculoskeletal and Skin Diseases(R01AR072703 to S.Du);supported in part by fellowships from the China Scholarship Council。
Skeletal and cardiac muscles are striated myofibers that contain highly organized sarcomeres for muscle contraction.Recent studies revealed that Smyd1,a lysine methyltransferase,plays a key role in sarcomere assembly ...
关键词：Smyd1 MYOSIN SARCOMERE Craniofacial muscle Cardiac muscle 
Seeking candidate variants of arrhythmogenic cardiomyopathy in sarcomere genes
《中国循环杂志》2018年第S01期139-139,共1页Kai Chen Jiangping Song Man Rao 
ObjectiveTo seek potential pathogenic variants in sarcomere genes in arrhythmogenic cardiomyopathy(ACM)and describe the characteristics.Methods and Results We performed targeted sequencing of 14sarcomere genes in 118 ...
关键词：arrhythmogenic CARDIOMYOPATHY SARCOMERE genes family MEMBERS of the probands 
Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy被引量：10
《World Journal of Diabetes》2015年第7期943-960,共18页Mark T Waddingham Amanda J Edgley Hirotsugu Tsuchimochi Darren J Kelly Mikiyasu Shirai James T Pearson 
The research funding from the International Synchrotron Access Program(AS/IA133)of the Australian Synchrotron(to Pearson JT);A Grant-in-Aid for Scientific Research(#E056,26670413)from the Ministry of Education,Culture,Sports,Sciences and Technology of Japan(to Shirai M)
Diabetes mellitus significantly increases the risk of cardiovascular disease and heart failure in patients.Independent of hypertension and coronary artery disease,diabetes is associated with a specific cardiomyopathy,...
关键词：Diabetes PREDIABETES Insulin resistance MYOCARDIUM SARCOMERE Protein KINASE C RHO KINASE 
Importance of genetic evaluation and testing in pediatric cardiomyopathy被引量：6
《World Journal of Cardiology》2014年第11期1156-1165,共10页Muhammad Tariq Stephanie M Ware 
Supported by The Children’s Cardiomyopathy Foundation;Cincinnati Children’s Hospital’s Clinical and Translational Science Award,No.NIH-ULl RR026314(Ware SM);and AHA Postdoctoral Fellowship Award,No.12POST10370002(Tariq M)
Pediatric cardiomyopathies are clinically heterogeneous heart muscle disorders that are responsible for significant morbidity and mortality. Phenotypes include hypertrophic cardiomyopathy, dilated cardiomyopathy, rest...
关键词：PEDIATRIC MUTATION Exome sequencing SARCOMERE 
Pediatric restrictive cardiomyopathy due to a heterozygous mutation of the TNNI3 gene被引量：3
《The Journal of Biomedical Research》2014年第1期59-63,共5页Yan Chen Shiwei Yang Jun Li Gannan Wang Yuming Qin Daowu Wang Kejiang Cao 
funded by the Natural Science Foundation of China (No.81000076);the Youth Education Program to Shi-wei YANG supported by Nanjing Health Bureau
Pediatric restrictive cardiomyopathy is rare and most commonly idiopathic in origin. Here, we applied a candi- date gene approach and identified a missense mutation in the cardiac troponin I gene in a 12-year-old Chin...
关键词：CARDIOMYOPATHY RESTRICTIVE sarcomere protein gene troponin I 
Functional Analysis of Slow Myosin Heavy Chain 1 and Myomesin-3 in Sarcomere Organization in Zebrafish Embryonic Slow Muscles被引量：6
《Journal of Genetics and Genomics》2012年第2期69-80,共12页Jin Xu Jie Gao Junling Li Liangyi Xue Kan J. Clark Stephen C. Ekker Shao Jun Du 
supported by a research grant(MB-8716-08) from United States-Israel Binational Agriculture Research and Development Fund to SJD and a NIH grant(DA14546) to SCE;Liangyi Xue was supported by a Pao Yu-Kong and Pao Zhao-Long Scholarship for Chinese Scholars Studying Abroad from Ningbo University,China
Myofibrillogenesis, the process of sarcomere formation, requires close interactions of sarcomeric proteins and various components of sarcomere structures. The myosin thick filaments and M-lines are two key components ...
关键词：MYOSIN Myomesin-3 M-LINE SARCOMERE 
Collective mechanism of molecular motors and a dynamic mechanical model for sarcomere被引量：5
《Science China(Technological Sciences)》2011年第8期2130-2137,共8页YIN YueHong GUO Zhao 
supported by the National Natural Science Foundation of China (Grant No. 61075101/60643002);the Research Fund of State Key Laboratory of MSV, China (Grant No. MSV-2010-1);the National High-Tech Research and Development Program of China (Grant No. 2006AA04Z240);the Shanghai Dawn Program (Grant No. 07SG14);the Medical and Technology Intercrossing Research Foundation of Shanghai Jiao Tong University (Grant No. YG2010ZD101)
A non-equilibrium statistical method is used to study the collective characteristics of myosin II motors in a sarcomere during its contraction. By means of Fokker-Planck equation of molecular motors, we present a dyna...
关键词：molecular motor myosin II actin filament SARCOMERE collective characteristics Fokker-Planck equation muscle force model 
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