MYOSIN

作品数:103被引量:202H指数:7
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相关作者:伏秀青赵威张志谦赵同军展永更多>>
相关机构:东北师范大学中国医科大学北京大学中国科学院大学更多>>
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力学信号通路ROCK-myosinⅡA调控肿瘤细胞cGAS介导抗肿瘤免疫应答的机制研究
《医用生物力学》2024年第S01期295-295,共1页刘迎琦 姚雪梅 李孟桓 罗忠 
国家自然科学基金项目,32122048;重大研究计划培育项目,92059107;国家重点研究计划子课题,2017YFB0702603;重庆市科技局重庆市杰出青年科学基金项目,cstc2021jcyj-jqX0022;重庆市组织部重庆市英才-青年拔尖人才支持计划,cstc2021ycjhbgzxm0124
目的异常的力学微环境是实体肿瘤重要的临床特征,能够通过组织硬度介导的力学信号通路影响抗肿瘤免疫应答的产生。方法此研究以力学微环境显著的肝癌和乳腺癌为研究对象,利用2D PVA水凝胶模拟不同硬度的细胞外基质用以培养肝癌或乳腺癌...
关键词:培养的肿瘤细胞 瘤内注射 细胞共培养 实体肿瘤 小鼠脾脏 乳腺癌细胞 细胞外基质 信号通路 
Bioinformatics Analysis of the Biological Properties of Ewing Sarcoma
《Journal of Biosciences and Medicines》2024年第6期202-215,共14页Luchang Chen Huifang Zeng Wujia Yang Haidong Zhou Changtai Luo Dong Luo Zhenjing Si Wei Wang Jihua Wei 
Purpose: Bioinformatics-based approach to screen and analyze differentially expressed genes associated with the biological characteristics of Ewing sarcoma. Means: The GSE17674 dataset was selected for analysis, obtai...
关键词:Ewings Sarcoma MYOSIN Bioinformatics Analysis Targeted Genes 
Alternative relay regulates the adenosine triphosphatase activity of Locusta migratoria striated muscle myosin
《Insect Science》2024年第2期435-447,共13页Jie Hao Chang Liu Ning Zhang Jing Li Tong Ni Mingbo Qu Xiang-dong Li 
supported by the National Natural Science Foundation of China(31672359 and 31970657);State Key Laboratory of Integrated Management of Pest Insects and Rodents(Grant No.IPM1601).
Locust(Locusta migratoria)has a single striated muscle myosin heavy chain(Mhc)gene,which contains 5 clusters of alternative exclusive exons and 1 differently included penultimate exon.The alternative exons of Mhc gene...
关键词:alternative splicing ATPASE Locusta migratoria molecular motor MUSCLE MYOSIN 
Myosin regulates intracellular force and guides collective cancer cell migration via the FAK-Rho/ROCK feedback loop
《Genes & Diseases》2023年第6期2199-2201,共3页Xiang Qin Yuchen He Yixi Zhang Shun Li Tingting Li Fengming You Yiyao Liu 
supported,in part or in whole,by the National Natural Science Foundation of China(No.32071304,U19A2006,12132004,11972111,and 32171309);the China Postdoctoral Science Foundation(No.2019T120821);the Natural Science Foundation of Sichuan Program(No.23NSFSC3552,2022NSFSC0048,2022NSFSC0686,23SYSX0108,and 2023NSFSC1233);the Joint Funds of Center for Engineering Medicine(No.ZYGX2021YGLH017).
Breast cancerhas been one of the biggest killers of women due to its susceptibility and high metastasis.Pathological observations show that malignant cancer cells frequently invade the surrounding normal tissue in col...
关键词:cancer COLLECTIVE MIGRATION 
Myosin 1H基因多态性与骨性错[牙合]畸形的研究进展
《临床口腔医学杂志》2023年第10期627-629,共3页王茜莹(综述) 王茜 祖丽乎马尔·帕尔哈提 米丛波(审校) 
国家自然科学基金项目(81960196)。
错[牙合]畸形是常见的颅颌面发育畸形,遗传因素在病因中占有重要地位。随着相关易感基因定位研究的不断深入,骨性错[牙合]畸形的遗传机制逐渐被揭示。Ⅰ类肌球蛋白基因(myosin 1H gene,MYO1H)负责调控肌肉纤维中的Ⅰ类肌球蛋白(Myosin 1...
关键词:骨性错[牙合]畸形 Ⅰ类肌球蛋白基因 单核苷酸多态性 
灰霉菌MyosinⅠ的体外表达纯化及抑制剂筛选被引量:2
《南京农业大学学报》2023年第3期482-488,共7页宋国红 刘松涛 李林蔚 刘飞 张峰 
江苏省农业自主创新资金[CX(20)3129];江苏省六大人才高峰高层次人才项目(NY-035)
[目的]本文旨在体外表达纯化灰霉菌Ⅰ型肌球蛋白(MyosinⅠ)及筛选抑制剂。[方法]采用SF9昆虫细胞蛋白表达系统表达灰霉菌MyosinⅠ(BcMyosinⅠ)马达结构域,用亲和层析和凝胶过滤层析纯化方法纯化蛋白,用SDS-PAGE和Western blot检测蛋白...
关键词:灰霉菌 MyosinⅠ 表达 纯化 抑制剂筛选 
Myosin 1D and the branched actin network control the condensation of p62 bodies被引量:3
《Cell Research》2022年第7期659-669,共11页Xuezhao Feng Wanqing Du Mingrui Ding Wenkang Zhao Xirenayi Xirefu Meisheng Ma Yuhui Zhuang Xiaoyu Fu Jiangfeng Shen Jinpei Zhang Xiuying Lei Daxiao Sun Qing Xi Yiliyasi Aisa Qian Chenr Ying Li Wenjuan Wang Shanjin Huang Li Yu Pilong Li Na Mi 
supported by the Ministry of Science and Technology of China(2017YFA0506300 to N.M.;2019YFA0508403 to P.L.);the National Natural Science Foundation of China(31771536,31860316).
Biomolecular condensation driven by liquid-liquid phase separation(LLPS)is key to assembly of membraneless organelles in numerous crucial pathways.It is largely unknown how cellular structures or components spatiotemp...
关键词:CONDENSATION P62 network 
Effects of different calcium salts on the physicochemical properties of sliver carp myosin被引量:2
《Food Bioscience》2022年第3期298-306,共9页Yang Hu Mengling Zhang Yu Zhao Xia Gao Juan You Tao Yin Shanbai Xiong Ru Liu 
financially supported by Agriculture Research System of China(No.CARS-45-28);National Natural Science Foundation of China(No.31471686,No.32172227).
To investigate the effects of different calcium salts on the physicochemical properties of myosin,the intermolecular interactions,particle size,surface hydrophobicity,reactive sulfhydryl group content and rheological ...
关键词:CALCIUM MYOSIN Gel properties Silver carp 
RhoGEF Trio Regulates Radial Migration of Projection Neurons via Its Distinct Domains被引量:2
《Neuroscience Bulletin》2022年第3期249-262,共14页Chengwen Wei Mengwen Sun Xiaoxuan Sun Hu Meng Qiongwei Li Kai Gao Weihua Yue Lifang Wang Dai Zhang Jun Li 
the Key Realm R&D Program of Guangdong Province(2019B030335001);the National Key R&D Program of China(2016YFC1307000);the National Natural Science Foundation of China(81730037,81825009,81871077,81671363,and 82071541);the Beijing Major Science and Technology Projects(Z181100001518001).
The radial migration of cortical pyramidal neurons(PNs)during corticogenesis is necessary for establishing a multilayered cerebral cortex.Neuronal migration defects are considered a critical etiology of neurodevelopme...
关键词:TRIO Myosin X RHOGEF NEURODEVELOPMENTAL DISORDER Radial migration 
Myosin X对肺癌H1975细胞系放射敏感性调节及机制探讨被引量:1
《中华放射肿瘤学杂志》2021年第9期949-955,共7页沈惠 欧海斌 邵晶 江耀飞 刘羽 张俊红 谢丛华 
国家自然科学基金项目(81001099,81370070);武汉大学中南医院科技创新培育基金(expy2017027);武汉大学中南医院医学科技创新平台支撑项目(PTXM2019030)。
目的探讨Myosin X对肺癌H1975细胞系放射敏感性调节及相关机制。方法蛋白免疫印迹法检测肺癌细胞系中Myosin X表达量以获取实验对象。运用CRISPR/Cas9技术建立敲除Myosin X的H1975细胞系(KO组)和感染对照病毒的H1975细胞系(NC组),并进...
关键词:肌球蛋白X CRISPR/Cas9技术 放射敏感性 H1975细胞系 
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