the Key Realm R&D Program of Guangdong Province(2019B030335001);the National Key R&D Program of China(2016YFC1307000);the National Natural Science Foundation of China(81730037,81825009,81871077,81671363,and 82071541);the Beijing Major Science and Technology Projects(Z181100001518001).
The radial migration of cortical pyramidal neurons(PNs)during corticogenesis is necessary for establishing a multilayered cerebral cortex.Neuronal migration defects are considered a critical etiology of neurodevelopme...
This work was supported by the Bioteclmology and Functional genomics(FUGE)programs of the Norwegian Research Council through grants NFR 159959,164583 and 151991(T B,P W and A M B);by grants from the National Science Foundation,the Department of Energy and the US Department of Agriculture(Z Y).
Rho GTPases are molecular switches that act as key regulators of a many cellular processes, including cell movement, morphogenesis, host defense, cell division and gene expression. Rho GTPases are found in all eukaryo...
We thank anonymous reviewers for their helpful comments.This work was supported by the National High-Tech Research and Development Program of China(Grant No.2003AA231030);the Excellent Young Teachers Program of the Ministry of Education of China(2003),and Beijing Normal University.
Domain insertions and deletions lead to variations in the domain architectures of the proteins from their common ancestor. In this work, we investigated four groups of the RhoGEF-containing proteins from different org...