A RHOse by any other name:a comparative analysis of animal and plant Rho GTPases  

作　　者：Tore Brembu Per Winge Atle Magnar Bones Zhenbiao Yang 

机构地区：[1]Department of Botany and Plant Sciences, Center for Plant Cell Biology, Institute of Integrative Genome Biology, University of California, Riverside, California 92521, USA [2]Department of Biology, University of Science and Technology, N-7491 Trondheim, Norway

出　　处：《Cell Research》2006年第5期435-445,共11页细胞研究（英文版）

基　　金：This work was supported by the Bioteclmology and Functional genomics(FUGE)programs of the Norwegian Research Council through grants NFR 159959,164583 and 151991(T B,P W and A M B);by grants from the National Science Foundation,the Department of Energy and the US Department of Agriculture(Z Y).

摘　　要：Rho GTPases are molecular switches that act as key regulators of a many cellular processes, including cell movement, morphogenesis, host defense, cell division and gene expression. Rho GTPases are found in all eukaryotic kingdoms. Plants lack clear homologs to conventional Rho GTPases found in yeast and animals; instead, they have over time developed a unique subfamily, ROPs, also known as RAC. The origin of ROP-like proteins appears to precede the appearance of land plants. This review aims to discuss the evolution of ROP/RAC and to compare plant ROP and animal Rho GTPases, focusing on similarities and differences in regulation of the GTPases and their downstream effectors.

关 键 词：Rho GTPase RHOGAP RHOGEF RHOGDI CYTOSKELETON NADPH oxidase RIC 

分 类 号：Q26[生物学—细胞生物学]