RHOGAP

作品数:10被引量:35H指数:3
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相关领域:医药卫生生物学更多>>
相关作者:叶文雨王成余文英鲁国东王宗华更多>>
相关机构:福建农林大学河北医科大学兰州大学第二医院中国热带农业科学院更多>>
相关期刊:《滨州医学院学报》《玉米科学》《Genomics, Proteomics & Bioinformatics》《中国药理学通报》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划更多>>
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DLC2在肿瘤中作用及机制的研究进展被引量:2
《中国药理学通报》2019年第7期911-914,共4页李晓曼 吴媛媛 王爱云 陈文星 陆茵 
国家自然科学基金资助项目(No 81703765);江苏省中药药效与安全性评价重点实验室资助项目(No JKLPSE201602,JKLPSE201610);江苏省高校中药学优势学科建设工程资助项目(PAPD)
DLC2是新近发现的抑癌基因,在肝癌、乳腺癌、胶质瘤等多种肿瘤中不表达或低表达。DLC2可增强RhoA、Cdc42的GTP酶活性,负性调控Rho蛋白活性及其下游效应分子,并可靶向定位于黏着斑;DLC2还可通过其SAM结构域与蛋白相互作用,促进蛋白泛素...
关键词:DLC2 STARD13 肿瘤发生发展 抑癌基因 RHOGAP ceRNA 
基因表达分析稻瘟病菌中8个假定RhoGAP蛋白与几丁质合酶的关系被引量:3
《基因组学与应用生物学》2016年第10期2724-2729,共6页叶文雨 豆献英 陈美莲 牛晓庆 杨雪 余文英 鲁国东 
国家自然科学基金(31500118;31571943)资助
通过分析稻瘟病菌Rho GAP家族基因与几丁质合酶家族基因的表达关系,研究该家族基因对细胞壁形成的影响。利用不同生物信息学软件对Rho GAP家族进行序列分析,运用RT-PCR技术获得了该家族基因的部分c DNA序列,通过实时荧光定量技术分析Rho...
关键词:稻瘟病菌 RHOGAP 生物信息学 几丁质合酶 Real.time PCR 
玉米弯孢叶斑病菌RhoGAP基因家族的全基因组鉴定与生物信息学分析被引量:2
《玉米科学》2015年第3期44-49,共6页王玉莹 侯巨梅 赵丰舟 申永强 左豫虎 刘铜 
国家自然基金项目(31101407;31272026;31301611);2013年黑龙江省研究生学术交流项目(黑教研[2013]145号)
RhoGAPs(GTPase activating proteins)通过与Rho GTP酶结合,促使GTP酶水解成Rho GDP无活状态,在生物体中调控着重要的生物学功能。在全基因组上对玉米弯孢叶斑病菌(C.lunata)中RhoGAP基因家族成员进行鉴定,对其序列特征分析。结果表明,...
关键词:玉米 RHOGAP 弯孢叶斑病菌 基因家族 基因结构 
Induction of entosis by epithelial cadherin expression被引量:14
《Cell Research》2014年第11期1288-1298,共11页Qiang Sun Edmund S Cibas Hongyan Huang Louis Hodgson Michael Overholtzer 
Acknowledgments We thank Drs Alan Hall and Xuejun Jiang and their lab members, and members of the Overholtzer laboratory for reagents and discussions on the manuscript. We thank Drs Keith R Johnson, Klaus Hahn, Michael Sheetz, Erik Sahai, and Tingchao Chou for reagents. This work was supported by grants from the NCI (CA154649, MO), the NIGMS (GM09312, LH), the Geoffrey Beene Cancer Research Center at MSKCC (MO), the Louis V Gerstner, Jr Young Investigators Fund (MO), the Benjamin Friedman Research Fund (MO), the National Basic Research Program of China (2015CB553704, QS), and the National Natural Science Foundation of China (30871364 and 81472588, QS).
Cell engulfment typically targets dead or dying cells for clearance from metazoan tissues. However, recent evidence demonstrates that live cells can also be targeted and that engulfment can cause cell death. Entosis i...
关键词:entosis CADHERIN Rho GTPase ACTOMYOSIN p190A RhoGAP tumor suppression 
抑癌基因DLC-1作为非小细胞肺癌研究新靶点的进展
《滨州医学院学报》2013年第5期366-368,371,共4页翟玉洁 陈绍水 
肺癌是严重威胁人类健康且预后最差的恶性肿瘤之一,近年来由于肺癌危险因素的改变及人口老龄化等多重作用下,我国肺癌发病率及病死率呈持续增高趋势。据世界卫生组织(WHO)预测,到2025年,我国每年新增的肺癌病死例数将超过100万,...
关键词:DLC-1 RHOGAP SAM START 肺癌 
稻瘟病菌RhoGAP基因表达特征及其生物信息学分析被引量:4
《热带作物学报》2013年第10期1991-1997,共7页叶文雨 胡芳辉 连璧 陈晓 余文英 鲁国东 陈继圣 王宗华 
国家自然科学基金(No.31030004;31300132)
Rho GAPs(GTPase activating proteins)是真核生物中Rho GTP酶的负调控因子之一,通过激活Rho GTP结合蛋白内在的GTP酶活性,使其加速水解成结合GDP的失活态。全基因组分析指出稻瘟病菌有8个Rho GAP成员(MoRhoGAP),但是其功能不清。本研...
关键词:MoRhoGAP 生物信息学 基因表达 稻瘟病菌 
肺腺癌组织p190-B RhoGAP蛋白表达及其与预后的相关性分析
《中华肿瘤防治杂志》2009年第19期1486-1489,共4页王成 李宝重 万军庭 谭小刚 邱斌 邢学忠 邵康 赫捷 张有成 
目的:探讨p190-B RhoGAP在肺腺癌组织中的表达及其临床和预后意义。方法:收集160例接受手术治疗的肺腺癌患者临床病理资料,应用免疫组化检测肺腺癌组织芯片中p190-B RhoGAP蛋白的表达,分析其与临床和预后的相关性。所有患者随访5年。结...
关键词:肺肿瘤 腺癌 免疫组织化学 
New member of the guanosine triphosphatase activating protein family in the human epididymis被引量:3
《Acta Biochimica et Biophysica Sinica》2008年第10期855-863,共9页Xiangqi Li Qiang Liu Shigui Liu Jinsong Zhang Yonglian Zhang 
This work was supported by the grants from the National Natural Science Foundation of China (30230190 and 30570684), the National Basic Science Research and Development Project (2006CB504002 and 2006CB944002) and the Chinese Academy of Sciences Knowledge Innovation Program (KSCX1-YW-R-54)Acknowledgements We would like to thank Shanghai Huashan Hospital (Shanghai, China) for the preparation of human tissues. We are also grateful to our colleagues for their fruitful discussions.
The effect of the guanosine triphosphatase activating proteins (GAPs) on spermatogenesis has been studied for years, though no GAPs have been explored in epididymis, an essential organ for sperm maturation. In this ...
关键词:EPIDIDYMIS MacGAP RHOGAP signal transduction 
Phylogenetic Analysis of RhoGAP Domain-Containing Proteins
《Genomics, Proteomics & Bioinformatics》2006年第3期182-188,共7页Marcelo M. Brando Karina L. Silva-Brando Fernando F. Costa Sara T.O. Saad 
Proteins containing an Rho GTPase-activating protein (RhoGAP) domain work as molecular switches involved in the regulation of diverse cellular functions. The ability of these GTPases to regulate a wide number of cel...
关键词:Bayesian analysis character tracing PARSIMONY PHYLOGENOMICS protein domain RhoGAP 
A RHOse by any other name:a comparative analysis of animal and plant Rho GTPases被引量:7
《Cell Research》2006年第5期435-445,共11页Tore Brembu Per Winge Atle Magnar Bones Zhenbiao Yang 
This work was supported by the Bioteclmology and Functional genomics(FUGE)programs of the Norwegian Research Council through grants NFR 159959,164583 and 151991(T B,P W and A M B);by grants from the National Science Foundation,the Department of Energy and the US Department of Agriculture(Z Y).
Rho GTPases are molecular switches that act as key regulators of a many cellular processes, including cell movement, morphogenesis, host defense, cell division and gene expression. Rho GTPases are found in all eukaryo...
关键词:Rho GTPase RHOGAP RHOGEF RHOGDI CYTOSKELETON NADPH oxidase RIC 
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