Acknowledgments We thank Drs Alan Hall and Xuejun Jiang and their lab members, and members of the Overholtzer laboratory for reagents and discussions on the manuscript. We thank Drs Keith R Johnson, Klaus Hahn, Michael Sheetz, Erik Sahai, and Tingchao Chou for reagents. This work was supported by grants from the NCI (CA154649, MO), the NIGMS (GM09312, LH), the Geoffrey Beene Cancer Research Center at MSKCC (MO), the Louis V Gerstner, Jr Young Investigators Fund (MO), the Benjamin Friedman Research Fund (MO), the National Basic Research Program of China (2015CB553704, QS), and the National Natural Science Foundation of China (30871364 and 81472588, QS).
Cell engulfment typically targets dead or dying cells for clearance from metazoan tissues. However, recent evidence demonstrates that live cells can also be targeted and that engulfment can cause cell death. Entosis i...
This work was supported by the grants from the National Natural Science Foundation of China (30230190 and 30570684), the National Basic Science Research and Development Project (2006CB504002 and 2006CB944002) and the Chinese Academy of Sciences Knowledge Innovation Program (KSCX1-YW-R-54)Acknowledgements We would like to thank Shanghai Huashan Hospital (Shanghai, China) for the preparation of human tissues. We are also grateful to our colleagues for their fruitful discussions.
The effect of the guanosine triphosphatase activating proteins (GAPs) on spermatogenesis has been studied for years, though no GAPs have been explored in epididymis, an essential organ for sperm maturation. In this ...
Proteins containing an Rho GTPase-activating protein (RhoGAP) domain work as molecular switches involved in the regulation of diverse cellular functions. The ability of these GTPases to regulate a wide number of cel...
This work was supported by the Bioteclmology and Functional genomics(FUGE)programs of the Norwegian Research Council through grants NFR 159959,164583 and 151991(T B,P W and A M B);by grants from the National Science Foundation,the Department of Energy and the US Department of Agriculture(Z Y).
Rho GTPases are molecular switches that act as key regulators of a many cellular processes, including cell movement, morphogenesis, host defense, cell division and gene expression. Rho GTPases are found in all eukaryo...