supported by the National Natural Science Foundation of China(32222022,92354301,92054104);Key Research and Development Program,Ministry of Science and Technology of China(2022YFC2303502,2021YFC2300204);Natural Science Foundation of Shanghai(23ZR1470900).
Hepatitis B virus(HBV),an enveloped DNA virus with a partially double-stranded DNA genome,causes transient and chronic hepatitis B in humans.A certain amount of chronic HBV infections eventually leads to liver cirrhos...
the National Natural Science Foundation of China(Grant No.32000951,51973129);the Sichuan Science and Technology Program(Grant No.2022YFS0147);the Science and Technology Achievement Transformation Fund of West China Hospital of Sichuan University(Grant No.CGZH19006);the Med-X Innovation Programme of Med-X Center for Materials of Sichuan University(Grant No.MCM202101);the 1.3.5 project for disciplines of excellence from West China Hospital of Sichuan University(Grant No.ZYJC21010);Med+Biomaterial Institute of West China Hospital/West China School of Medicine of Sichuan University(Grant No.ZYME20001).
Cellular behaviors and functions can be regulated by mechanical cues from microenvironments,which are transmitted to nucleus through the physical connections of cytoskeletons in the cells.How these physical connection...
supported by the grants from National Natural Science Foundation of China(82072929,82072943,and 31870752,China).
Tumor metastasis depends on the dynamic balance of the actomyosin cytoskeleton.As a key component of actomyosin filaments,non-muscle myosin-ⅡA disassembly contributes to tumor cell spreading and migration.However,its...
It is critical to combat tumor metastasis by eradicating disseminated tumor cells in any step during the metastasis process.After entering the blood circulation system,tumor cells are in suspension and experience cons...
the support from National Natural Science Foundation of China ( 11672255);Shenzhen Science and Technology Innovation Commission ( JCYJ20170303160515987, JCYJ20170413154735522 );Early Career Scheme from Research Grants Council of the Hong Kong Special Administrative Region,China ( PolyU 252094 /17E);the internal grant from the Hong Kong Polytechnic University ( 1-ZE4Q,1-ZVJ8)
Metastasis is the main cause of cancer death,and tumor cells mainly disseminate to the distal organs through the blood circulation,in which they experience considerable levels of fluid shear stress.CTCs are heterogene...
The migration of cortical interneurons is a fundamental process for the establishment of cortical connectivity and its impairment underlies several neurological disorders. During development, these neurons are born in...
SUMMARY Directional movement of cellular components is essen- tial to all eukaryotic cells, and is driven by a mecha- noenzymatic system consisting largely of the actin- myosin cytoskeletal protein complex. Structural...
Acknowledgments We thank Drs Alan Hall and Xuejun Jiang and their lab members, and members of the Overholtzer laboratory for reagents and discussions on the manuscript. We thank Drs Keith R Johnson, Klaus Hahn, Michael Sheetz, Erik Sahai, and Tingchao Chou for reagents. This work was supported by grants from the NCI (CA154649, MO), the NIGMS (GM09312, LH), the Geoffrey Beene Cancer Research Center at MSKCC (MO), the Louis V Gerstner, Jr Young Investigators Fund (MO), the Benjamin Friedman Research Fund (MO), the National Basic Research Program of China (2015CB553704, QS), and the National Natural Science Foundation of China (30871364 and 81472588, QS).
Cell engulfment typically targets dead or dying cells for clearance from metazoan tissues. However, recent evidence demonstrates that live cells can also be targeted and that engulfment can cause cell death. Entosis i...
Reepithelialization of skin which comprises epidermis and dermis has not been fully elucidated due to the complexity of the participants as well as the interactions therein. In this study, the intrinsic roles and beha...
Phagocytosis of opsonized pathogens by circulating non-adherent neutrophils is an essential step in host defense, which when overwhelmed contributes to sepsis. To investigate the role played by ligation of complement ...