卡马西平对癫痫患者SCE频率的影响及其与叶酸的关系  

Relationship between the effect of carbamazepine on SCE frequencies and folic acid in epileptic patients

作　　者：李蜀渝 吕冰清 杨晓苏 陈朝晖 

出　　处：《湖南医科大学学报》1999年第6期563-565,共3页Bulletin of Hunan Medical University

摘　　要：检测15 例单服卡马西平(CBZ) 及15 例服用CBZ 加叶酸(FA) 的癫痫患者外周血淋巴细胞姊妹染色单体交换(SCE) 频率,同时用放射免疫法测定其血清叶酸值,并与未服药癫痫对照组及正常对照组进行比较。结果显示,单服CBZ 组的SCE 频率较服用CBZ加FA 组及对照组高,其血清FA 值下降。提示CBZ可引起癫痫患者SCE 频率升高、血清叶酸值减少,补充叶酸可有效防止CBZ 引起的染色体DNAPeripheral blood lymphocyte sister chromatid exchange(SCE) frequencies, serum folic acid(FA) levels were examined in 15 epileptic patients treated with carbamazepine(CBZ), and another 15 epileptic patients treated with CBZ and folic acid(FA). The untreated epileptic patients and the healthy subjects served as control. The results showed that SCE frequencies were significantly higher in CBZ Group, compared with CBZ plus FA Group and control(P<0.01). Serum FA levels were lower in CBZ Group compared with healthy control(P<0.01). It suggests that CBZ can induce the increase of SCE frequencies. Supplementation with FA may effectively prevent chromosome DNA damage induced by CBZ.

关 键 词：卡马西平 癫痫 叶酸 SCE频率 

分 类 号：R742.1[医药卫生—神经病学与精神病学]