A new pregnane-type glycoside from Reineckia carnea  

吉祥草中的一个新甾体皂苷(英文)

作　　者：邢鹏鹏[1] 吴琼[1] 吴再旺[1] 付宏征[1] 

机构地区：[1]北京大学医学部天然药物及仿生药物国家重点实验室,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》2011年第4期347-351,共5页中国药学（英文版）

基　　金：National Natural Science Foundation of China (Grant No.30973628)

摘　　要：The aim of current study was to investigate the chemical components of the aerial part of Reineckia carnea,collected in Yunnan Province of China.Repeated column chromatography（CC）separations were performed to isolate and purify components. Compounds were identified by the analysis of their 1D and 2D NMR data as well as IR and MS spectra.A new pregnane-type glycoside,named 1α,3β-diol-5β-pregn-16-ene-20-one-1-O-α-L-arabinosyl-（1→2）-α-L-rhamnoside（1）,together withβ-amyrin（2）, stigmasterol（3）,α-spinasterol-3-O-β-D-glucoside（4）,naringenin（5）,β-sitosterol（6）and daucosterol（7）,were isolated from ethyl acetate（EtOAc）and normal butanol（n-BuOH）extracts.Compounds 2,4,5 were isolated from this plant for the first time.对吉祥草地上部分的化学成分进行研究。采用多种色谱手段进行分离纯化,得到单体化合物,通过理化性质及1D,2DNMR方法确定了化合物的结构。分离得到一个新的孕甾烷型甾体皂苷,命名为1α,3β-dihydroxy-5β-pregn-16-ene-20-one-1-O-αL-arabinosy1-(1→2)-α-L-rhamnoside。另鉴定了6个已知化合物,分别为β-香树脂醇(2),豆甾醇(3),α-菠甾醇-3-O-葡萄糖苷(4),柚皮素(5),β-谷甾醇(6),胡萝卜苷(7),其中化合物2,4,5为首次在该植物中分离得到。

关 键 词：Reineckia carnea Steroid saponin SAPONIN 

分 类 号：R284.2[医药卫生—中药学]