血清TGF-β_1及VEGF在慢性乙肝、肝纤维化、肝硬化患者的临床变化及其意义  

The Changes and Significance of Serum TGF-β_1,VEGF in Patients with Chronic Hepatitis B,Liver Fibrosis and Liver Cirrhosis

作　　者：李晓虹[1] 杨蒲芳[1] 戚红霞[1] 陈范嵘[1] 

机构地区：[1]上海市普陀区人民医院消化科,上海200060

出　　处：《临床消化病杂志》2011年第3期144-145,162,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：目的探讨慢性乙型肝炎、肝纤维化、肝硬化患者血清转化生长因子TGF-β1及血管内皮生长因子(VEGF)的临床变化及其意义。方法采用酶联免疫法(ELISA)分别测定正常对照组30例,慢性乙型肝炎组40例,肝纤维化组32例,肝硬化组36例的血清TGF-β1及VEGF值。结果慢性乙肝组TGF-β1浓度明显增高(P<0.01);VEGF与对照组无差异。随着肝纤维化及肝硬化的形成,TGF-β1、VEGF浓度明显增高(P<0.01,P<0.001)。患者TGF-β1及VEGF测定值呈正相关(r=0.337,P<0.05)。结论 TGF-β1及VEGF与肝纤维化及肝硬化的形成密切相关,二者血清浓度联合检测可作为病情发展评估的指标。Objective To evaluate the significance of serum transforming growth factor--β1 （ TGF- -β1） and vascular endothelial growth factor （VEGF） in patients with chronic hepatitis B, liver fibrosis and liver cirrhosis. Methods Serum TGF- -β1 and VEGF were detected by enzyme-linked immunoassay （ELISA） in 30 controls, 40 patients with chronic hepatitis B, 32 patients with liver fibrosis and 36 patiems with liver cirrhosis. Results With the development from liver fibrosis to cirrhosis, the levels of serum TGF--β1 and VEGF became higher and higher（P 〈0.01 ,P 〈0. 001 ）. The levels of VEGF in patients with chronic hepatitis B is similar to those of healthy controls （ P 〉 0. 05 ）. The levels of TGF-β1 were positively correlated with VEGF （r = 0. 337 ,P 〈 0.05 ）in patients. Conclusion TGF-β1 and VEGF may play important roles in the pathogenesis of liver fibrosis and cirrhosis. The serum levels of them are closely associated with the severity and prognosis of the liver disease.

关 键 词：慢性乙型肝炎 肝纤维化 肝硬化 血管内皮生长因子 转化生长因子-Β1 

分 类 号：R575.2[医药卫生—消化系统]