pRb2/p130在子宫颈癌中的表达  

The expression of pRb2/p130 Gene in human cervical cancer

作　　者：沈芳荣 陈友国[2] 冯亚红 杨丹丹[2] 

机构地区：[1]江苏省苏州市九龙医院,215021 [2]苏州大学附属第一医院

出　　处：《中国妇幼保健》2011年第19期3006-3007,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨子宫颈正常组织及病变组织中pRb2/p130的表达及其与子宫颈癌临床病理特征的关系。方法:应用免疫组化SP法检测60例患者子宫颈标本的pRb2/p130的表达,其中宫颈浸润癌10例,宫颈原位癌15例,宫颈上皮内瘤变(C IN)Ⅰ-Ⅱ期15例,正常宫颈组织20例。结果:pRb2/p130阳性表达率在正常宫颈组织、C IN、宫颈原位癌、宫颈浸润癌组织中依次递减,分别为85.0%、80.0%、26.6%、20.0%,且宫颈浸润癌和宫颈原位癌(C IS)中明显低于正常宫颈组织及C IN组织,差异均有统计学意义(P<0.05)。结论:在子宫颈癌中pRb2/p130的表达下降或缺失是一个频发事件,其恶性程度愈高表达阳性率愈低,提示pRb2/p130与子宫颈癌的发生、发展密切相关,并在其发病机制中起着重要的作用。Objective：To investigate the expression of pRb2/p130 gene and the pathological clinical features relationship with human cervical cancer.Methods：The levels of pRb2/p130 protein were examined with immunohistochemical SP method in 10 samples of invasive cervical cancer,15 samples of carcinoma in situ（CIS）,15 samples of cervical intraepithelial neoplasia（CIN）and 20 samples of normal cervix.Results：The positive rate of pRb2/p130 protein in the normal cervix,CIN,CIS and invasive cancer was respectively 85.0%,80.0%,26.6% and 20.0%.pRb2/p130 protein in invasive cancer and CIS was significantly lower than that in normal tissue（P0.05）.The positive expression of pRb2/p130 gene was related to histological differentiation（P0.05）.Conclusion：Descent or miss of the expression of pRb2/p130 gene is a frequent incidence in human cervical cancer.The positive rate of pRb2/p130 expression is proportionate to malignant degree of endometrial carcinoma,indicating that pRb2/p130 plays an important role in the development and pathogenesis of cervical cancer.

关 键 词：子宫颈癌 PRB2/P130 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]