口服云南白药对下颌阻生智齿拔除术后面部肿胀影响的评价  

Evaluation of the effect of Yunnan Baiyao on postoperative swelling after the extraction of the mandibular impacted third molar

作　　者：董辉[1] 郭婷婷[1] 周侠 冯春丽[1] 夏登胜[1] 

机构地区：[1]首都医科大学口腔医学院综合科,北京100050 [2]北京大学口腔医学院颌面外科,北京100020

出　　处：《首都医科大学学报》2011年第3期421-425,共5页Journal of Capital Medical University

基　　金：国家科技部重大新药创制专项(2008ZX09202)~~

摘　　要：目的评价口服云南白药对埋伏下颌阻生智齿拔除术后面部反应性肿胀的缓解情况。方法 48例下颌埋伏阻生智齿患者按随机数字表法分为实验组和对照组,每组24例,于术前3 d开始,连续8 d口服云南白药胶囊或安慰剂胶囊。分别在术前以及术后第1天、第3天和第5天进行面部三维扫描,重建面部三维模型,利用逆向工程技术软件测定术后不同时间点面部肿胀的体积和厚度,分析两组患者术后面部肿胀度、疼痛强度和张口度。结果口服云南白药组和口服安慰剂组在不同时间点所测定的疼痛强度和张口度差别均无统计学意义,而2组间面部肿胀厚度和肿胀度差异有统计学意义。结论下颌埋伏阻生智齿拔除术中采用围术期口服云南白药胶囊对预防和治疗术后面部反应性肿胀有一定的疗效。Objective To evaluate the effect of oral administration of Yunnan Baiyao on the reduction of postoperative pain,swelling and trismus after the extraction of the mandibular impacted third molar.Methods According to the completely random double-blind design,48 enrolled patients were divided into experimental and control groups equally.Patients were orally administered with Yunnan Baiyao capsules or placebo capsules for 8 days,starting from 3 days before the operation.Three-dimensional facial scans of patients were performed in the preoperative and postoperative first day,third and fifth day respectively,and the facial three-dimensional images were reconstructed.Using reverse engineering software,the facial swelling degree,pain intensity and trismus in different time points were quantified and analyzed.Results There were no statistical significance in trismus,pain intensity and swollen volume between the two groups.The facial swelling thickness and swelling degree had significant statistical differences between the two groups.Conclusion Oral administration of Yunnan Baiyao capsules in the perioperative period can prevent and reduce the facial swelling after the extraction of the mandibular impacted third molar.

关 键 词：云南白药 下颌阻生第三磨牙 面部肿胀 三维面部重建 

分 类 号：R78[医药卫生—口腔医学]