外燥对小鼠气道免疫分子影响的实验研究  

Effects on the Respiratory Immunological Molecules of Mise in Outer-Dry

作　　者：张六通[1] 丁建中[2] 王明明[1] 胡利群[2] 王昌富[2] 贺尚荣[2] 

机构地区：[1]湖北中医药大学,武汉430061 [2]湖北长江大学医学院,荆州434023

出　　处：《中国中医药现代远程教育》2011年第11期159-160,共2页Chinese Medicine Modern Distance Education of China

基　　金：国家自然科学基金资助项目[30672572]

摘　　要：目的动态观察外燥对小鼠气道液免疫分子的影响。方法 40只SPF级昆明小鼠随机分为常温常湿组(A组)、常温燥组(B组)、温燥组(C组)、凉燥组(D组),每组10只。处理后第6、12、18天检测各组气道液中分泌型IgA(SIgA)、IgG和肿瘤坏死因子(TNF-a)。结果与燥相关三个组第6～18天TNF-α、IgG同期下降,温燥组第6～18天TNF-a、IgG与SIgA均持续降低。结论再次证实,外燥伤肺耗津之时,可降低气道"纤毛-黏液毯"免疫御邪屏障,是外燥损伤"正气"为病之精细病机之一。Aim To investigate the effects on the immunological molecules of respiratory in Outer-Dry.Methods 40 kunming mice（SPF） were divided into four groups：group A（normal）,group B（normal temperature and Outer-Dry）,groupC（Warm-Dry）,group D（Cool-Dry）,10mices/group.SIgA、 IgG and Tumor Necrosis Factor-a（TNF-a）of mice＇respiratory were measured in day 6,12 and 18.Results Compared with group A,IgG-R and TNF-a of group B,C and D were reduced,SIgA,IgG and TNF-a of group C were noticeable weaked in day 6 to 18.Conlusion The results were repeated indicated that the remarkable injuring of immunological molecules of ＂respiratory mucus barrier＂were related with the mechanisms of Outer-Dry with disordering of＂secretion and the transport＂of＂lung-fluid＂.

关 键 词：外燥 小鼠 气道液 免疫分子 

分 类 号：R228[医药卫生—中医基础理论]