^(125)I粒子食管支架治疗晚期食管癌30例临床分析  

^(125)I particle esophageal stent in the treatment of 30 patients with advanced esophageal cancer

作　　者：罗友海 姜在波[2] 黄明声[2] 庞鹏飞[2] 樊国兆 俞思全 杨双 

机构地区：[1]四川省广元市苍溪人民医院,四川628400 [2]广东省中山大学附属第三医院介入血管科,广东510630

出　　处：《当代医学》2011年第14期65-66,共2页Contemporary Medicine

摘　　要：目的 125I同位素粒子食管内照射支架治疗晚期食管癌的临床疗效观察。方法对30例晚期食管癌患者行125I同位素粒子食管内照射支架治疗,术后进行临床及影像学随访。结果 30例患者顺利置入支架30枚(直径18～20mm,长径6～10cm),手术成功率100%。30例患者术前吞钡造影均显示病变部位狭窄程度>80%,术后病变处管腔恢复至正常内径的90～100%。患者吞咽困难改善100%,卡氏评分≥60分者由术前的11例增加至25例。术后3月CT示病变较术前部分缓解15例,进展5例,稳定10例。30例患者生存期为6～20.5个月,平均约为9.9个月。结论 125I粒子食管内照射支架为晚期食管癌患者提供了一种较为理想的治疗方式。Objective： To observe clinical results of expandable esophageal stent loaded with 125I seeds for advanced esophageal cancer.Materials and Methods： 30 patients who suffered from advanced esophageal cancer received expandable esophageal stent loaded with 125I seeds deployment.Clinical and imaging follow up were performed post procedure.Results： Stents,diameter,18-20mm;length,6-10mm,were successfully deployed in 30 patients.Barium meal study pre procedure showed all patients had esophageal stenoses greater than 80%.Stenotic lumina recovered to 90-100% of normal diameter after stent placement.Partial response（n=15）,progressive disease（n=5） and stable disease（n=10） were found in 30 patients at the third follow up month by using CT angiography.Overall survival was 6-20.5 month,mean 9.9 month.All patients had improved dysphagia after stent deployment.25 patients had Karnofsky score ≥60 after procedure compared with 11 patients before operation.Conclusion： Expandable esophageal stent loaded with 125I seeds was an ideal therapeutic approach for patients with advanced esophageal cancer.

关 键 词：125I同位素粒子 食管支架 晚期食管癌 

分 类 号：R735.1[医药卫生—肿瘤]