神经生长因子对大鼠脑缺血再灌注后TGF-β1和IL-1β表达的影响及临床意义  

Effect of Nerve Growth Factor on Expression of Transforming Growth Factor-β1 and Interleukin-1β after Cerebral Ischemical Reperfusion in Rats and the Clinical Significance

作　　者：王洪津[1] 白艳娟[1] 辛世萌[1] 

机构地区：[1]大连医科大学附属第二医院神经内科,辽宁大连116023

出　　处：《医学与哲学（B）》2011年第6期55-56,64,共3页Medicine & Philosophy(B)

摘　　要：探讨神经生长因子(NGF)的脑保护作用及临床意义。采用大鼠脑缺血再灌注(MCAO)模型,选取健康成年SD大鼠55只,随机分为假手术组(n=5)、对照组(n=30),NGF组(n=10)和生理盐水对照组(n=10)进行造模,应用免疫组化方法检测TGF-β1和IL-1β的表达。可见NGF组神经功能障碍明显减轻,TGF-β1表达量增多,IL-1β的表达量减少(P(0.01)。肌注NGF对脑缺血再灌注有明显的保护作用,NGF在临床上可用于治疗急性脑梗死。To investigate the brain protecting mechanism and clinical significance of nerve growth factor（NGF） . Applying cerebral isehemical reperfusion（ MCAO）model of SD rats. 55 healthy adult SD rats were randomly divided into a false surgical operation group（ n = 5 ）, control group （ n = 30 ）, NGF group （ n=10 ） and matched group（ n = 10 ） to established the MCAO model. To examine expression of TGF-β1 and IL-1β after the immunity histochemistry in rats brain. The nerve function harrier of NGF group obviously reduced, the expressional quantity of IL-1β increased, that of TGF-β1 reduced（P〈0. 01 ）. NGF（via intramuscular injection） is of obvious protective function on ischemia--reperfusion rats brain. NGF could be used to cure acute cerebral infarct.

关 键 词：神经生长因子 缺血再灌注 TGF-β1 IL-1β 脑梗死 

分 类 号：R743[医药卫生—神经病学与精神病学]