脂蛋白相关磷脂酶A2基因Val279Phe和Ile198Thr突变与脑梗死的相关性  

Correlation between Vai279Phe, lle198Thr nutation in fipoprotein- associated phosphofipase A2 gene and cerebral infarction

作　　者：吴健 张雄 袁成林 张桁忠 俞龙 

机构地区：[1]扬州大学临床医学院神经内科,225001

出　　处：《国际脑血管病杂志》2011年第6期437-441,共5页International Journal of Cerebrovascular Diseases

基　　金：江苏省社会发展计划科技基金（BS2002021）

摘　　要：目的探讨脂蛋白相关磷脂酶A2（1ipoprotein-associatedphospholipase A2，Lp—PLA2）基因Val279Phe和Ilel98Thr突变与江苏省汉族人脑梗死的关系。方法纳入150例江苏省汉族人脑梗死患者和100名健康对照者，应用聚合酶链反应和变性高效液相色谱法分析Lp—PL九基因Val279Phe和Ilel98Thr突变与脑梗死之间的关系。结果脑梗死组Val279Phe基因型和突变等位基因频率显著高于对照组（χ2分别为6．31和5．32，P均〈0．05），而Ilel98Thr基因型和突变等位基因频率与对照组无显著差异（χ2分别为0．039和0．037，P均〉0．05）。结论Lp—PLA2基因Val279Phe突变可能是江苏省汉族人脑梗死的遗传学危险因素。Objective To investigate the correlation between the mutation in serum lipoprotein-associated phospholipase A2（Lp-PLA2） Ile198Thr, Val279Phe and cerebral infarction in Chinese Han population of Jiangsu Province. Methods One hundred fifty patients with cerebral infarction and 100 healthy controls in Chinese Hart population of Jiangsu Province were recruited. The correlation between Va1279Phe and Ile198Thr mutation in Lp-PLA2 gene and cerebral infarction was analyzed using polymerase chain reaction and denaturing high perform- ance liquid chromatography. Results The Va1279Phe genotype and the mutant allele frequency in the cerebral infarction group were significantly higher than those in the control group （χ2 were 6. 31and 5.32, respectively, all P 〈0. 05）, and there was no significant difference between the Ile198Thr genotype and the mutant allele frequency in the control ffoup （χ2 were 0. 039 and 0. 037, respectively, all P 〉0. 05）. Conclusions The Va1279Phe mutation in Lp-PLA2 gene may be a genetic risk factor for cerebral infarction in Chinese Han population of Jiangsu Province.

关 键 词：1-烷基-2-乙酰甘油磷酸胆碱酯酶 磷脂酶A2 脑梗死 多态现象 遗传学 生物学标记 

分 类 号：R74[医药卫生—神经病学与精神病学]