阿尔茨海默病与动脉硬化及其危险因素的关系探讨  

Alzheimer disease and arteriosclerosis and their risk factors

作　　者：肖军[1] 陈祥慧[1] 易刚[1] 周波[1] 冯琼华[1] 

机构地区：[1]四川省医学科学院.四川省人民医院神经内科,四川成都610072

出　　处：《实用医院临床杂志》2011年第4期69-72,共4页Practical Journal of Clinical Medicine

基　　金：四川省卫生厅科研基金资助项目(编号:080332)

摘　　要：目的探讨阿尔茨海默病(Alzheimer disease,AD)与动脉硬化及其危险因素之间的关系。方法选取临床诊断为AD患者106例作为观察组,认知功能正常老年人80例为对照组。两组性别、职业及受教育程度相匹配,分析两组中高血压、糖尿病、血脂代谢异常、颈部血管狭窄及斑块、颈部血管内膜增厚、颅内血流速度减慢、吸烟、饮酒以及脑梗死的分布情况。以Logistic回归模型分析各因素与AD的关系。结果高血压、糖尿病、血脂代谢异常、颈部血管狭窄及斑块、颈部血管内膜增厚、双侧大脑前、中、后动脉血流速度减慢以及脑梗死在AD与对照组之间差异有统计学意义(P<0.05),而吸烟、饮酒在AD与对照组之间差异无统计学意义(P>0.05)。结论 AD与血管性因素有关,高血压、糖尿病、血脂代谢异常、脑梗死、颈部血管狭窄及斑块、颈部血管内膜增厚、颅内血流速度减慢是AD的独立危险因素。Objective To investigate the relationship between Alzheimer disease（AD）and arteriosclerosis and their risk factors.Methods A case-control study including 106 AD patients and 80 cognitive normal controls was conducted.The patients and controls were matched for gender,occupation and education level.It analyzed the two cases of high blood pressure,diabetes,abnormal lipid metabolism,cerebral infarction,neck vessel stenosis and plaque,intimal thickening of the neck,intracranial blood flow slowed down,smoking,drinking the distribution of liquor.The relationship between AD and vascular factors was analyzed by Logistic model.The level of statistical significance of differences in multivariate analysis was P0.05.Results Hypertension,diabetes,abnormal lipid metabolism,cerebral infarction,neck vessels＇ stenosis and plaque,intimal thickening of the neck vessels,anterior cerebral artery,middle,cerebral artery,posterior cerebral artery＇s blood flow slowed down in between the AD and the control group significantly difference（P0.05）.Smoking,drinking in between AD and control groups were not significantly different（P0.05）.Conclusion AD is associated to vascular factors.High blood pressure,diabetes,abnormal lipid metabolism,cerebral infarction,neck vessels stenosis and plaque,intimal thickening of the neck vessels,intracranial blood flow velocity is slowed down the independence of the risk of AD factors.

关 键 词：阿尔茨海默病 动脉硬化 认知功能 危险因素 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R543.5[医药卫生—临床医学]