头颅MR、DWI、MRS、术中快速冰冻与脑胶质瘤病理分级对比  

Comparative study among MR imaging,DWI perfusion,fast-frozen and pathological evaluation of tumor grade of gliomas

作　　者：赵东晖[1] 李庆军[2] 何建芳[1] 方学文[3] 卢义生[1] 

机构地区：[1]广东东莞市人民医院病理科,东莞523000 [2]广东东莞市人民医院神经内科,东莞523000 [3]广东东莞市人民医院放射科,东莞523000

出　　处：《中国实用神经疾病杂志》2011年第11期4-7,共4页Chinese Journal of Practical Nervous Diseases

基　　金：东莞市科技计划项目(编号:B200921)

摘　　要：目的对比分析磁共振扩散加权成像（DWI）、表现弥散系数（ADC）值和磁共振波谱（MRS）、术中快速冰冻与脑胶质瘤病理分级对比分析,为胶质瘤术前、术中诊断和分级提供更详实的依据。方法对37例脑胶质瘤患者行磁共振检查,测定肿瘤实质部分、对照侧ADC值、其比值（rADC）;测定脑胶质瘤中代谢产物N-乙酰天门冬氨酸（NAA）、胆碱（Cho）、肌酸（cr）水平及其比值,将结果与术中和术后病理对比分析。结果低级别胶质瘤（1-2级）ADC值和rADC值高于高级别胶质瘤（3-4级）（P〈0.05）,与肿瘤病理分级呈负相关,NAA/Cho和NAA/Cr与肿瘤级别呈明显负相关（P〈0.05）,Cho/Cr与胶质瘤级别呈正相关（P〈0.05）,磁共振病理分级与病理分级准确率81.7%。结论 ADC值和MRS与胶质瘤病理分级有相关性。Objective To evaluate the correlations among MRI,diffusion-weighted imaging（DWI）,apparent diffusion coefficient（ADC）,magnetic resonance spectroscope（MRS）,fast-frozen and pathological evaluation of tumor grade of gliomas by comparing the related parameter.Methods The conventional MR imaging and 1H-MRS were performed in 37 cases of gliomas.The density of metabolin and the Cho/Cr,Cho/NAA values were observed.The comparison of tumor grade of gliomas performed by MR imaging and pathology was done.Results There were significant differences between low-grade gliomas and high-grade gliomas in ADC value（P0.05）.There were correlations between the grade of gliomas and the values of NAA/Cho,NAA/Cr and Cho/Cr.The concordance rate of tumor grade of gliomas between MR imaging and pathology was 81.7%.Conclusion There is correlation between the pathological evaluation of tumor grade of gliomas and the values of ADC and MRS.

关 键 词：胶质瘤 分级 免疫组化 磁共振 

分 类 号：R739.4[医药卫生—肿瘤]