Pokemon、Ki－67蛋白在胃癌中的表达和临床意义  

Expression and clinical significance of Pokemon and Ki - 67 proteins in gastric cancer

作　　者：韩晓峰[1] 李月锋[1] 曲宏岩[1] 

机构地区：[1]哈尔滨医科大学附属第三医院胃肠外科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2011年第3期219-222,共4页Practical Oncology Journal

基　　金：黑龙江省哈尔滨市科技创新人才研究专项资金项目（2008RFQXS096）

摘　　要：目的探讨Pokemon、Ki-67蛋白在胃正常黏膜与胃癌组织中的表达及其意义。方法应用RT—PCR法检测25例胃正常黏膜及125例胃癌组织中Pokemon、Ki-67蛋白的表达，并联系临床病理学指标进行相关分析。结果在正常胃黏膜中Pokemon和Ki-67不表达或弱表达，在胃癌组织中表达增高，并与TNM分期及有无淋巴转移有关，与年龄、性别、肿瘤大小无关。结论Pokemon、Ki-67蛋白的表达与胃癌的发生、发展和转移密切相关，可能共同参与了胃癌的发生、发展。Pokemon有望成为胃癌治疗的一个有效靶基因，从而为胃癌基因治疗开辟新的途径。Objective To study the expression of Pokemon,Ki -67 and its clinical significance in gastric cancer and normal gastric mucosa. Methods The Pokemon and Ki- 67 in gastric cancer（ n = 125 ）, normal gastric mucosa（n = 25 ）was detected by RT - PCR. Results Pokemon protein expression was high in gastric cancer group,which was significantly different from the expression in normal gastric mucosa. It was highly expressed in gastric cancer and was related with stage of TNM and lymph node metastasis, but were not related with the age,sex and the size of tumor. Conclusion Pokemon and Ki - 67 protein expression may be correlate with the carcinogenesis and genesis, development and metastasis of gastric cancer. Pokemon may be an effective target gene for therapy of gastric cancer, accordingly,which may develop a new way of gene therapy for gastric cancer.

关 键 词：胃癌 POKEMON基因 原癌基因 RT—PCR KI-67 

分 类 号：R735.2[医药卫生—肿瘤]