三维适形放疗联合同步化疗治疗食管癌31例疗效观察  

3-dimensional conformal radiotherapy combined with concurrent chemotherapy for esophageal cancer

作　　者：刘静景[1] 段诗苗[1] 蔡汉飞[1] 江浩[1] 

机构地区：[1]蚌埠医学院第一附属医院放疗科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2011年第6期606-608,共3页Journal of Bengbu Medical College

摘　　要：目的:评价三维适形放疗(3DCRT)联合同步化疗治疗食管癌的局部控制率、生存期和毒副作用。方法:31例食管癌患者应用3DCRT 1.8～2 Gy/f,总放射剂量55～65 Gy;同步行化疗,放疗开始第1天应用顺铂30 mg/m2静脉滴注,每周1次至放疗结束。放疗结束后行2周期辅助化疗,顺铂20 mg静脉滴注5天,替加氟1.0 g静脉滴注5天,28天为1个周期。结果:完全缓解22例,部分缓解7例,无变化2例,总有效率为93.55%;进食梗阻缓解率为96.77%。1、2、3年局部控制率分别为88%、51%、40%;1、2、3年生存率分别为93%、66%、58%;均发生急性放射性食管炎,≥3级占15%;白细胞下降发生率为56%,≥3级占34%。结论:3DCRT联合同步顺铂方案治疗食管癌可提高局部控制率并延长生存期,毒副反应可耐受。Objective： To evaluate the efficacy of 3-dimensional conformal radiotherapy （3DCRT） combined with concurrent chemotherapy in management of esophageal carcinoma. Methods：From Feb. 2006 to Aug. 2007,31 patients with esophageal carcinoma were treated by 3DCRT at a dose of 1.8 -2 Gy/f（55 -65 Gy in total）;at the same time, cisplatin 30 mg/m2 was administered intravenously on the first day of each week until the end of the radiotherapy. After the therapy, chemotherapy regimen of cisplatin 20 mg plus tegafur 1.0 g were administered on day 1 to 5,every 28 days for two cycles. Results： Complete relief was observed in 22 cases, partial relief in 7 cases and no response in 2 cases,the overall response rate reached 93% ;the food intake obstruction was relieved in 97% of the cases;the 1,2 and 3-year local control rates were 88% ,51%and 40% ,respectively;the 1,2 and 3-year survival rates were 93% ,66% and 58% ,respectively. Acute radiations esoph-agitis occurred in 100% of the cases,and 15% of them were at a grade of 〉~3;leucopenia was observed in 56% of the cases, and 34% of them were at a grade of 〉/3. Conclusions：3DCRT combined with chemotherapy is an effective and well-tolerated regimen for treatment of patients with esophageal cancer.

关 键 词：食管肿瘤 放射治疗/三维适形 化学治疗/同步 

分 类 号：R735.1[医药卫生—肿瘤]