两个α-氨基酸类二肽肽酶Ⅳ抑制剂的合成  

Synthesis of Two Dipeptidyl Peptidase Ⅳ Inhibitors of α-Amino Acid Derivatives

作　　者：朱燕云[1] 宋恭华[1] 卢鹏 

机构地区：[1]华东理工大学药学院,上海200237 [2]上海阳帆医药有限公司,上海201203

出　　处：《合成化学》2011年第4期557-560,共4页Chinese Journal of Synthetic Chemistry

摘　　要：以2,4,5-三氟苯甲酸为原料,经还原、溴代、烷基化、脱羧、脱乙酰基保护、上Boc-保护、酯水解、偶联、脱Boc-保护和成盐十步反应,合成了两个α-氨基酸类二肽肽酶Ⅳ抑制剂,α-氨基酸类衍生物,总收率23%,其结构经1H NMR,13C NMR和MS表征。Two dipeptidyl peptidase Ⅳ inhibitors,α-amino acid derivatives,were synthesized from 2,4,5-trifluorobenzoic acid by a ten-step reaction of reduction,Br-substitution,alkylation,decarboxylation,deacylation,Boc-protection,hydrolysis of ester,coupling reaction,deprotection and convertion to salt in total yield of 23%.The structures were characterized by 1H NMR,13C NMR and MS.

关 键 词：氨基酸 二肽肽酶Ⅳ抑制剂 合成 

分 类 号：O629.71[理学—有机化学] R914.5[理学—化学]