离子液体中Yb(OTf)_3催化下喹唑啉酮衍生物的绿色合成  

A clean synthesis of quinazolinone derivatives catalyzed by Yb(OTf)_3 in ionic liquid

作　　者：张海燕 盛洁[2] 王香善[2] 

机构地区：[1]徐州宇家化工科技有限公司,江苏徐州221002 [2]徐州师范大学化学化工学院,江苏徐州221116

出　　处：《徐州师范大学学报（自然科学版）》2011年第2期70-73,78,共5页Journal of Xuzhou Normal University(Natural Science Edition)

基　　金：江苏省高校自然科学基金资助项目(08KJD150019);江苏省"青蓝工程"创新团队项目(08QLT001)

摘　　要：在离子液体中,邻氨基苯甲酰肼首先和芳酮反应形成腙;在Yb(OTf)3(摩尔比为0.010)催化下,再与另外一分子酮反应,构建一系列不同取代的喹唑啉酮衍生物.产物的结构通过IR,1HNMR和HRMS表征.该方法具有操作简便、条件温和、绿色高效的优点.By using ionic liquid as a green reaction medium,aromatic ketones react with 2-aminobenzohydrazide to give hydrazone first,and then a series of quinazolinone derivatives are obtained by the reaction of hydrazone with another molecule of ketone catalyzed by Yb（OTf）3 of mole ratio 0.010.The structures of products were characterized by spectroscopic data of IR,^1HNMR and HRMS.This method has the advantages of easier work-up,milder reaction conditions,higher yields and environmentally benign procedure.

关 键 词：喹唑啉酮 离子液体 三氟甲磺酸镱 

分 类 号：O626.3[理学—有机化学]