血浆D-二聚体和细胞因子与老年肺炎相关性研究  

A Correlational Study of Plasma D-Dimer and Cytokines with Senile Pneumonia

作　　者：程莉[1] 陈永[1] 张劼[1] 刘茜[1] 甘丹[1] 田华[1] 

机构地区：[1]重庆市第三人民医院,重庆400014

出　　处：《中国药业》2011年第13期51-53,共3页China Pharmaceuticals

摘　　要：目的研究血浆D-二聚体和血液、痰液中促炎症细胞因子质量浓度与老年肺炎的相关性,探讨其对老年肺炎早期诊断、严重度分级和预后判断的价值。方法检测2006年1月至2010年8月确诊为老年肺炎的80例患者血浆D-二聚体和血液、痰液中促炎症细胞因子白细胞介素6(IL-6)、白细胞介素8(IL-8)、肿瘤坏死因子-α(TNF-α)的质量浓度,分析D-二聚体与促炎症细胞因子质量浓度的相关性,比较不同CURB-65评分组患者血浆D-二聚体和血液、痰液中促炎症细胞因子质量浓度以及死亡率的差异。结果老年肺炎患者抗感染治疗前后血浆D-二聚体和血液中促炎症细胞因子IL-6,IL-8,TNF-α的质量浓度均高于对照组,痰液促炎症细胞因子质量浓度明显高于血液促炎症细胞因子质量浓度;血浆D-二聚体与促炎症细胞因子质量浓度呈正相关,且与痰液促炎症细胞因子相关性更强;患者CURB-65评分越高,血浆D-二聚体和血液、痰液促炎症细胞因子质量浓度越高,死亡率也越高,各CURB-65评分组间死亡率差异有统计学意义。结论检测血浆D-二聚体和痰液促炎症细胞因子的质量浓度,可能对老年肺炎的早期诊断、严重度分级和预后判断有重要意义。Objective To analyze the correlation between D-dimer in plasma and proinflammatory cytokines in blood and sputum with senile pneumonia and to explore their value to early diagnosis,severity classification and prognosis of senile pneumonia.Methods To measure the concentrations of plasma D-dimer and proinflammatory cytokines IL-6,IL-8 and TNF-αboth in blood and sputum in 80 elder patients diagnosed pneumonia from January 2006 to August 2010.To analyze the correlation between D-dimer and proinflammatory cytokines.To compare the difference in mortality and concentration of D-dimer and proinflammatory cytokines among different groups divided by CURB-65 score.Results The concentrations of D-dimer and proinflammtory cytokines before and after anti-infection treatment in the elder cases of pneumonia were higher than those in the control groups.The mass concentration of proinflammatory cytokines was higher in sputum than in blood.Plasma D-dimer was positively correlated with proinflammatory cytokines,and highly correlated with cytokines in sputum.The higher CURB-65 score was,the higher D-dimer,cytokines and mortality would be.There were statistically significant differences in mortality among various CURB-65 groups.Conclusion It is important and valuable to messure plasma D-dimer and sputum proinflammatory cytokines in early diagnosis,severity classification and prognosis of senile pneumonia.

关 键 词：老年 肺炎 血浆D-二聚体 细胞因子 相关性 

分 类 号：R363.27[医药卫生—病理学] R446[医药卫生—基础医学]