胶质瘤中肿瘤干细胞的分布及与p53、MGMT的关系  

Distribution of tumor stem cell and the relationship with p53 and MGMT in glioma

作　　者：柯金[1] 胡喜梅[1] 周水阳[1] 何杰[2] 朱海清[3] 

机构地区：[1]上海交通大学附属上海市第一人民医院松江分院血液肿瘤科,上海201600 [2]苏州大学附属第四医院病理科,江苏无锡214062 [3]南京医科大学附属脑科医院病理科,江苏南京210029

出　　处：《现代肿瘤医学》2011年第7期1322-1324,共3页Journal of Modern Oncology

摘　　要：目的:探讨胶质瘤中肿瘤干细胞标志物CD133的表达及其与p53、MGMT的关系。方法:采用免疫组化法检测45例不同病理级别胶质瘤标本中CD133和p53、MGMT蛋白的表达。结果:CD133在各病理级别的胶质瘤中均有表达,高恶性度组中CD133表达高于低恶性度组(P<0.05)。在CD133阳性组中p53、MG-MT的表达明显高于CD133阴性组(P均<0.05)。结论:不同恶性程度的胶质瘤标本中均存在肿瘤干细胞,肿瘤干细胞可作为判断胶质瘤恶性程度和预后的重要指标。Objective：To investigate the expression of tumor stem cell marker CD133 in glioma tissues and the relationship with p53 and MGMT.Methods：Expressions of CD133,p53 and MGMT in 45 cases of glioma tissues were detected by immunohistochemcal method.Results：CD133 could be observed in glioma tissues,and there was a significant difference between the expression of CD133 in high malignant gliomas and that in lowmalignant gliomas（P0.05）.The differences of p53 and MGMT expressions were statistically significant in the CD133-positive glioma group and the CD133-negative glioma group（P0.05）.Conclusion：Tumor stem cell could be detected in glioma,and can serve as an important marker in evaluating glioma malignancy and prognoses.

关 键 词：CD133 胶质瘤 肿瘤干细胞 

分 类 号：R730.3[医药卫生—肿瘤]