HIF-1α和PTEN基因在肾细胞癌中表达的相关性及临床意义  

Clinical significance and relationships between HIF-1α and PTEN expression in renal cell carcinoma

作　　者：张伟[1] 杨文增[1] 申岩[1] 张彦桥[1] 马涛[1] 崔振宇[1] 

机构地区：[1]河北大学附属医院泌尿外科,河北保定071000

出　　处：《现代肿瘤医学》2011年第7期1364-1367,共4页Journal of Modern Oncology

摘　　要：目的:探讨抑癌基因PTEN与HIF-1α在肾细胞癌中的表达及相互关系。方法:用免疫组化S-P法检测80例肾细胞癌、40例癌旁肾组织,10例非瘤正常肾组织中PTEN及HIF-1α的表达,将表达结果与临床分期、组织学分级及淋巴转移等生物学行为进行相关分析。结果:PTEN蛋白表达与肾癌Robson分期及组织学分级呈负相关,HIF-1α蛋白表达与肾癌Robson分期及组织学分级呈正相关。PTEN阳性表达组HIF-1α阳性表达率为42.3%,PTEN阴性表达组HIF-1α阳性表达率为85.7%,两者显著负相关(r=-0.419,P<0.01)。结论:PTEN及HIF-1α的表达与肾癌的组织学分级、临床分期和淋巴结转移密切相关,可作为判断肿瘤浸润进展的指标。Objective：To explore the expression level and the interrelation between PTEN and HIF-1α in renal cancer.Methods： The expression of PTEN and HIF-1α was examined by immunohistochemistry Streptavidin-Peroxidase method in 40 cases of para-carcinoma,10 cases of normal renal tissues and 80 cases of renal cell carcinoma.Results of PTEN and HIF-1α protein expression were compared with the clinical stage,pathological grade,lymphatic metastasis.Results： The relationship between the expression of PTEN and Robson staging showed negative rank correlation,whereas the relationship between the expression of HIF-1α and Robson staging showed positive correlation.The relationship between the expression of PTEN and that of HIF-1α showed negative correlation significantly（r=-0.419,P0.01）.The positive expression of HIF-1α protein was 42.3% in the group with positive high expression of PTEN protein,in the contrary,it displayed 85.7% in the group with low expression of PTEN protein.Conclusion： PTEN and HIF-1α are closely related to clinical stage,pathological grade and lymp nodes metastasis.It clould be a marker of the development of tumor.

关 键 词：肾细胞癌 PTEN HIF-1Α 蛋白表达 免疫组织化学 

分 类 号：R737.11[医药卫生—肿瘤]