卵巢上皮性癌组织中结肠癌转移相关基因1的表达及其临床意义  

Expression of MACC1 in epithelial ovarian cancer and its clinical significance

作　　者：黄好亮[1] 史惠蓉[1] 张瑞涛[1] 陈志敏[1] 刘惠娜[1] 苑中甫[1] 

机构地区：[1]郑州大学第一附属医院妇产科,郑州450052

出　　处：《肿瘤》2011年第6期522-526,共5页Tumor

摘　　要：目的:探讨卵巢上皮性癌组织中结肠癌转移相关基因1(metastasis-associated in colon cancer-1,MACC1)的表达及其临床意义。方法:应用RT-PCR和免疫组织化学法检测卵巢上皮性癌组织、卵巢上皮性良性肿瘤组织及正常卵巢组织中MACC1 mRNA及蛋白的表达,分析MACC1蛋白的表达与卵巢上皮性癌患者临床病理特征之间的关系。结果:卵巢上皮性癌组织中MACC1 mRNA和蛋白的表达水平均明显高于卵巢上皮性良性肿瘤组织和正常卵巢组织(P<0.05)。卵巢上皮性良性肿瘤组织与正常卵巢组织之间MACC1 mRNA和蛋白的表达水平无明显差异(P>0.05)。MACC1蛋白的阳性表达率与卵巢上皮性癌患者的临床分期、组织分化程度和淋巴结转移等因素相关(P<0.05)。结论:MACC1蛋白表达与卵巢上皮性癌患者的临床分期、组织分化程度和淋巴结转移相关。MACC1可能参与了卵巢上皮性癌的发生和发展。Objective：To investigate the expression of metastasis-associated in colon cancer 1（MACC1） in epithetial ovarian cancer and its clinical significance.Methods：The expressions of MACC1 mRNA and protein in epithelial ovarian cancer,benign epithelial ovarian tumor and normal ovarian tissues were detected by reverse transcription-polymerase chain reaction（RT-PCR） and immunohistochemistry method,respectively.The relationship between MACC1 protein expression and the clinicopathological features of patients with epithelial ovarian cancer were analyzed.Results：The expression levels of MACC1 mRNA and protein were higher in epithelial ovarian cancer tissues than those in the benign epithelial ovarian tumor and normal ovarian tissues（P〈0.05）,whereas there was no difference between the benign epithelial ovarian and the normal ovarian tissues（P〉0.05）.The positive expression rate of MACC1 protein was related with the clinical stage,the degree of histological differentiation and the lymph node metastasis in patients with epithelial ovarian cancer（P〈0.05）.Conclusion：The positive expression of MACC1 protein is related with the clinical stage,the degree of histological differentiation and the lymph node metastasis in patients with epithelial ovarian cancer.MACC1 may be involved in carcinogenesis and progression of epithelial ovarian cancer.

关 键 词：卵巢肿瘤 逆转录酶聚核酶链反应 免疫组织化学 结肠癌转移相关基因1 

分 类 号：R737.31[医药卫生—肿瘤]