液基薄层细胞学检测技术在肺癌诊断中的应用  

Application of Liquid-Based Cytology Test in the Diagnosis of Lung Cancer

作　　者：张恒[1] 徐亮[1] 闵生萍[1] 

机构地区：[1]安徽省蚌埠医学院第一附属医院肺科实验室,233004

出　　处：《中华全科医学》2011年第8期1296-1297,1302,共3页Chinese Journal of General Practice

摘　　要：目的探讨液基薄层细胞学检测技术(LCT)在肺癌纤支镜刷检中的应用价值。方法复阅应用LCT技术制片进行纤维支气管镜刷片细胞学诊断的患者涂片,并收集其临床病理资料,选取561例同时进行刷检液基薄层细胞学检查(LCT),刷检传统涂片细胞学检查(CS)和组织病理学(活检和/或手术)检查的患者资料,计算LCT和CS法的敏感度、特异性及分型的符合率。结果 LCT和CS法诊断肺癌敏感度分别为78.64%和62.91%,LCT检测的敏感度高于CS法(P<0.05);两者的特异性分别为97.78%和94.07%,特异性差异无统计学意义(P(0.05)。同时有LCT和CS细胞学及组织病理学分型诊断结果的264例患者中,鳞癌、腺癌和小细胞癌LCT细胞学诊断与病理诊断的分型符合率分别为96.73%、70.97%和97.50%。结论 LCT是在支气管刷检制片、染色等方面便于实施质量控制的一项新技术,在肺癌诊断中具有较高的敏感度、特异性以及分型诊断符合率,但差分化腺癌是分型诊断的一个难点。Objective To explore the diagnostic value of Liquid-based cytology test（LCT） for lung cancer in bronchoscopically biopsied specimens.Methods 561 cases of bronchoscopically biopsied specimens were identified for lung cancer with liquid-based cytology test（LCT） as well as conventional smear test（CS）.The results were analyzed for the sensitivity,specificity and concordance with pathology in the two methods.Results The sensitivity of LCT and CS for lung cancer identification were 78.64% and 62.91%,respectively,the difference was significant（P﹤0.05）,whereas the specificity were 97.78% and 94.07%,respectively.Analysis for the concordance between cytology and pathology in 264 specimens revealed that the identity rate of LCT was 96.73% in squamous carcinoma,71.97% in adenocarcinoma and 97.50% in small cell carcinoma.Conclusion LCT was an effective and practicable method for the identification of lung cancer,except for the type of poorly differentiated adenocarcinoma,with higher sensitivity and specificity comparable with CS test.

关 键 词：纤维支气管镜刷片 液基薄层细胞学检测技术 传统涂片细胞学检查 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]