替吉奥胶囊联合紫杉醇治疗晚期胃癌28例临床观察  

Clinical observation of the effects of the combination of S-1 and Paclitaxel in the treatment of patients with thwenty-eight patients of advanced gastric carcinoma

作　　者：周恒根[1] 倪敬中[1] 刘兰芳[1] 程燕[1] 李亚莉[1] 李华年[1] 

机构地区：[1]邳州市人民医院肿瘤科,221300

出　　处：《中国现代药物应用》2011年第11期3-4,共2页Chinese Journal of Modern Drug Application

摘　　要：目的观察替吉奥胶囊(S-1)联合紫杉醇治疗晚期胃癌的近期疗效和毒副反应。方法初治和复治的晚期胃癌28例,替吉奥胶囊80mg/(m2·d),2次/d,连服14d,停药7d;紫杉醇160mg/m2,第1天静脉滴注,21d为1个周期,连用2周期后评价疗效。结果总有效率53.6%(15/28)。主要毒副反应为胃肠道反应、白细胞减少,Ⅲ～Ⅳ度各占7.2%(2/28)。结论治疗晚期胃癌,替吉奥胶囊联合紫杉醇21d方案是有效、经济和安全的。Objective To evaluate the efficacy and toxicity of the combination of S-1 and Paclitaxel in the treatment of patients with advanced gastric carcinoma.Methods 28 previous patients with advanced gastric carcinoma were treated with S-1 and Paclitaxel.Chemotherapy consisted of S2-1 80 mg/（m2·d） given orally twice a day on days 1 to 14 of a 21-day cycle,concurrently with paclitaxel 160 mg/m2 on the first day,the evaluation of efficacy and toxicity were performed on all patients after 2 cycles.Results The tumor response rate observed in this study was 53.6%（15 /28）.Commonly occurring adverse events included nausea and vomiting,grade Ⅲ-Ⅳ neutropenia 7.2（2/28）.Conclusion The regimen S2-1 and Paclitaxel have shown activity in patients with advanced gastric carcinoma.The toxicity is mild and tolerable.

关 键 词：晚期胃癌 联合化疗 替吉奥胶囊 紫杉醇 

分 类 号：R735.2[医药卫生—肿瘤]