PVA/β-CD复合水凝胶的制备和性能研究  

Synthesis and properties of PVA/β-CD composite hydrogels

作　　者：王晓燕[1] 左奕[1] 高世博[1] 黄棣[1] 李玉宝[1] 

机构地区：[1]四川大学分析测试中心纳米生物材料研究中心,四川成都610064

出　　处：《功能材料》2011年第7期1203-1206,1210,共5页Journal of Functional Materials

基　　金：国家重点基础研究发展计划(973计划)资助项目(2007CB936102)

摘　　要：采用溶液共混法将β-环糊精(β-CD)添加到聚乙烯醇(PVA)中,然后通过冷冻-解冻法制备了PVA和β-CD复合水凝胶。通过核磁共振、红外、扫描电镜、X射线衍射、热重分析对材料的结构与性能进行表征,并研究了材料的亲疏水性及其细胞相容性。结果表明PVA和β-CD可用于制备新型PVA/β-CD复合水凝胶。通过改变β-CD的添加量可调节复合水凝胶的亲疏水性。初步体外细胞实验表明该复合水凝胶无细胞毒性。PVP/β-CD复合水凝胶是一种有发展前景的生物材料。Poly（vinyl alcohol） /β-cyclodextrin（PVA/β-CD） composite hydrogels were prepared by co-solution method and treated with repeated freeze-thawing recycle.The composite material was analyzed by nuclear magnetic resonance,infrared spectroscopy,scanning electron microscopy,X-ray diffraction and thermogravimetric analysis.The hydrophilicity and cytocompatibility were also tested.The results showed that new hybrid system of PVA/β-CD had been successfully prepared.The hydrophilicity of the composite can be adjusted by the amount of β-CD.The PVA/β-CD composite hydrogel exhibited good cytocompatibility,showing promising prospect as a new biomaterial.

关 键 词：聚乙烯醇 Β-环糊精 水凝胶 

分 类 号：TQ325[化学工程—合成树脂塑料工业] R318[医药卫生—生物医学工程]