维吾尔药阿育魏实化学成分的分离与鉴定  

Isolation and identification of chemical constituents from the seeds of Trachyspermum ammi(L.)Sprague,a traditional uygur medicine

作　　者：马庆东[1] 李国玉[1] 王航宇[1] 张珂[1] 王金辉[1,2] 

机构地区：[1]石河子大学药学院教育部省部共建新疆特种植物药资源重点实验室,新疆石河子832002 [2]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2011年第7期526-529,共4页Journal of Shenyang Pharmaceutical University

基　　金：国家重大科技专项资助(项目编号:2010ZX09401-304-104A)

摘　　要：目的研究新疆维吾尔药材阿育魏实中的化学成分。方法采用硅胶柱色谱及Sephadex LH-20分离化合物,运用现代波谱技术确定所得化合物结构。结果从阿育魏实乙醇提取物分离得到5个化合物,分别鉴定为4-羟基薄荷-1-烯-7-酸(4-hydroxymenth-1-en-7-oic acid,1)、E-3-(3,4-二羟基苯基)-丙烯酸3-(3,4-二羟基苯基)丙酯[E-3-(3,4-dihydroxyphenyl)propyl 3-(3,4-dihydroxyphe-nyl)acrylate,2]、6-羟基麝香草酚6-O-β-D-葡萄糖苷(6-hydroxythymol 6-O-β-D-glucopyranoside,3)、麝香草氢醌6-O-6'-乙酰基-β-D-葡萄糖苷(thymohydroquinone 6-O-6'-acetyl-β-D-glucopyranoside,4),对羟基桂皮酸(4-hydroxycinnamic acid,5)。结论化合物1、2为新天然产物,化合物4首次从伞形科植物分离得到。Objective To study chemical constituents from the seeds of Trachyspermum ammi（L.）Sprague.Methods The compounds were isolated by chromatography on silica gel column and identified by physical-chemical properties and spectral analysis.Results Five compounds were obtained and identified as 4-hydroxymenth-1-en-7-oic acid（1）,E-3-（3,4-dihydroxyphenyl）propyl 3-（3,4-dihydroxyphenyl）acrylate（2）,6-hydroxythymol 6-O-β-D-glucopyranoside（3）,thymohydroquinone 6-O-6′-acetyl-β-D-glucopyranoside（4）,and 4-hydroxycinnamic acid（5）.Conclusions Compounds 1 and 2 are new natural products,and compound 4 is isolated from Umbelliferae for the firs time.

关 键 词：阿育魏实 伞形科 4-羟基薄荷-1-烯-7-酸 E-3-(3 4-二羟基苯基)-丙烯酸3-(3 4-二羟基苯基)丙酯 

分 类 号：R914[医药卫生—药物化学]