MUC16介导卵巢癌细胞免疫逃逸NK细胞杀伤的研究进展  

The research development of potent suppression mechanisms of NK cells response mediated by MUC16 in epithelial ovarian cancer

作　　者：金夏[1] 赵卫东[1] 

机构地区：[1]安徽医科大学附属省立医院妇产科,合肥230001

出　　处：《国际免疫学杂志》2011年第4期287-289,共3页International Journal of Immunology

基　　金：安徽省科技攻关计划项目（08010302101）

摘　　要：过继性自体NK细胞免疫治疗临床应用的效果不明显可能与肿瘤在恶化过程中对NK细胞的免疫逃逸有关，MUC16作为一种表达于卵巢癌上皮细胞表面的跨膜黏蛋白可能参与了卵巢癌细胞对NK细胞杀伤作用的免疫逃逸。因而了解MUC16介导卵巢癌细胞免疫逃逸NK细胞杀伤作用的相关性研究很重要。The fact that there is no significant clinical benefit of autologous NK cell immunotherapy may be associated with the immune escape of ovarian cells in tumor progression . MUC16 is a membrane spanning mucin that is expressed on ovarian surface epithelial cells. This mucin may participate in the immune escape of ovarian cancer cells to NK cell killing effect . In this review, we summarized the relative researches about potent suppression mechanisms of NK cells response mediated by MUC16 in epithelial ovarian cancer.

关 键 词：NK细胞 上皮性卵巢癌 黏蛋白 免疫突触 

分 类 号：R737.31[医药卫生—肿瘤]