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作 者:陆明鸣[1] 陆潭[2] 张雪明[1] 张李阳[2] 陈玉胜[2]
机构地区:[1]南京晓庄学院行知学院,江苏南京211171 [2]南京晓庄学院生物化工与环境工程学院,江苏南京210017
出 处:《安徽农业科学》2011年第18期10818-10819,共2页Journal of Anhui Agricultural Sciences
基 金:江苏省高等学校大学生实践创新项目(2160081)
摘 要:[目的]探讨通过"固体双向发酵"工程技术生产的药性菌质的抗忧郁功效。[方法]将雄性ICR小鼠随机分为5组,即阴性对照组(0.9%生理盐水)、阳性对照组(市售盐酸氟西汀)、高剂量组(690.0 mg/kg)、中剂量组(345.0 mg/kg)和低剂量组(172.5 mg/kg),在灌胃给予受试物15 d后对各组小鼠进行开场试验(OFT)、悬尾试验(TST)和强迫游泳试验(FST),探讨芝芪菌质对小鼠行为学的影响。[结果]中剂量组芝芪菌质和阳性对照组能显著缩TST和FST小鼠悬尾和游泳不动时间,对小鼠开场行为无显著影响。[结论]芝芪菌质水提物具有一定的抗抑郁作用。[ Objective ] To explore the antidepressant effects of medicinal tungal substance which was produced lrom the engineering tecnnmogy of "bidirectional solid fermentation". [ Method ] Male ICR mice were randomly subdivided into five groups namely negative control group (0.9% normal saline) positive control group (fluoxetine hydroehloride purchased from market) high dosage group(690.0 mg/kg), middle dosage group (345.0 mg,/kg )and low dosage group( 172.5 mg/kg), The mice were given corresponding solution per day respectively. Fifteen days later, they were subjected to the open-field test (OFT), tails suspension test (TST) and forced swimming test (PST), evaluating the effects of solution eX- tracted from Zhiqi medicinal fungal substance on mice behavior [Result] The extracts of Zhiqi medicinal fungal substance significantly redtieed the immobility duration of mice in TST and FST after exercised in positive control)control group and middle dosage group ,while it had no effect oit open field behavior of mice. [ Conclusion] The solution extracted from Zhiqi medicinal fungal substance possesses definite antidepressant properties. Key words Zhiqi medicinal fungal substance; Antidepreant, Open-field test (OFT) ; Tails suspension test (TST) ; Forced swimming test (FST)
关 键 词:芝芪菌质 抗抑郁 开场试验(OFT) 悬尾试验(TST) 强迫游泳试验(FST)
分 类 号:S567[农业科学—中草药栽培]
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