海南树仔菜的大鼠胚胎毒性及致畸性研究  

EMBRYOTOXICITY AND TERATOGENICITY OF SAUROPUS ANDROGYNUS IN RATS

作　　者：郑定仙[1] 黄业宇[1] 林卫华[1] 冯丁山[1] 吴爱琴[1] 张晓昕[1] 王湛[1] 

机构地区：[1]海南省疾病预防控制中心,海口570203

出　　处：《现代预防医学》2011年第14期2803-2804,2812,共3页Modern Preventive Medicine

基　　金：海南省自然科学基金项目(80698)

摘　　要：[目的]了解海南树仔菜对大鼠胚胎毒性及致畸性。[方法]将孕鼠随机分成4组(阴性对照组、树仔菜干粉低、中、高剂量组),每组12只。于受孕的d7～16,各组分别灌胃给予树仔菜干粉0,250,500,1000mg/kg,于受孕的d0、7、12、16、20称体重。d20断头处死孕鼠,检查胎鼠的死亡情况、外观、体重、体长、尾长。1/2胎鼠制作内脏标本,其余制作骨骼标本。[结果]各剂量组孕鼠体重、胚胎形成与发育、各项畸形指标与阴性对照组比较,差异无统计学意义(P﹥0.05)。[结论]海南树仔菜无母体毒性、胚胎毒性及致畸性。[Objective] To observe the embryotoxicity and teratogenicity of Sauropus androgynus planted in Hainan in rats.[Methods]The pregnant rats were randomly divided into four groups of twelve rats each（negative conthol group,low,moderate and high dose group of Sauropus androgynus power）.Sauropus androgynus power was orally administered to the pregnant rats from the 7th to 16th days of gestation at doses of 0,250,500,1 000 mg/kg.The maternal body weight was recorded at days 0,7,12,16 and 20 of gestation.The pregnant rats were sacrificed,the death,external,body weight,body length and tail length of the fetal rats were examined at the 20th day of gestation.Half the fetuses were prepared in Bouins for visceral examination and the remaining for skeletal.[Results]All of the indications in each dose group were not significantly different compared with negative control group（P﹥0.05）.[Conclusion]No the maternal toxic,embryotoxicity and teratogenicity of the sauropus androgynus were observed.

关 键 词：海南树仔菜 胚胎毒性 致畸性 

分 类 号：R394.6[医药卫生—医学遗传学]