上感颗粒对不同中医证型病毒性上呼吸道感染发热患者的退热疗效  

Effect of Shanggan Granules on Different TCM Syndromes of Viral Upper Respiratory Tract Infection Patients with Fever

作　　者：奚肇庆[1] 余衍亮[1] 刘清泉[2] 张晓云[3] 罗翌[4] 张念志[5] 孙伯青[6] 孙菊光 杜梁枫[8] 郑艳[9] 卜擎燕[1] 邹建东[1] 芮庆林[1] 张丽[9] 刘夕宁[9] 曾亮[9] 耿连艺[9] 熊宁宁[1] 

机构地区：[1]江苏省中医院急诊科 [2]北京中医药大学东直门医院 [3]成都中医药大学附属医院 [4]广东省中医院 [5]安徽中医学院附属医院 [6]江苏省昆山市中医医院 [7]江苏省徐州市中医院 [8]江苏省无锡市第三人民医院 [9]南京中医药大学

出　　处：《中医杂志》2011年第14期1199-1202,共4页Journal of Traditional Chinese Medicine

基　　金：2008年度中医药行业科研专项资助项目(200807041)

摘　　要：目的评价上感颗粒治疗病毒性上呼吸道感染发热适用的中医证型。方法收集8个中心433例病毒性上呼吸道感染发热患者,分为风寒证、风热证、卫气同病、风邪袭表-寒热不显、风邪袭表-寒热兼夹5个证型,均给予上感颗粒口服,体温<39.0℃时,每日1剂;体温≥39.0℃时,每日2剂,疗程3d。观察各证型患者地域分布情况、即刻退热作用、退热时间及综合疗效。结果各证型组体温在给药后2h、3h和4h与给药前比较差异均有统计学意义(P<0.05或P<0.01);各证型患者起效时间比较差异无统计学意义(P>0.05);与风寒证比较,风热证、卫气同病证患者退热时间差异有统计学意义(P<0.05);风邪袭表-寒热兼夹、卫气同病证型的临床痊愈率最高,与风寒证、风邪袭表-寒热不显证型差异有统计学意义(P<0.05或P<0.01)。结论上感颗粒对病毒性上呼吸道感染发热患者风寒证、风热证、卫气同病、风邪袭表-寒热不显、风邪袭表-寒热兼夹5种证型疗效确切,对寒热兼夹、卫气同病、风热证疗效更佳。Objective To evaluate the indicated TCM syndromes of Shanggan Granules （Granule for upper respiratory tract infection） in the treatment of fever of viral upper respiratory tract infection. Methods Totally 433 viral upper respiratory tract infection patients were collected from the 8 centers. They were diagnosed into 5 syndromes, including wind cold, wind heat, weifen and qifen diseased simultaneously, wind attacking the exterior -uncertain cold or heat, and wind attacking the exterior - cold and heat in complication. All were administered Shanggan Granules, one dose per day in case the body temperature was below 39.0℃, two doses per day if the body temperature was over 39.0℃, for 3 days in succession. The regional distribution of every syndrome, instant antifebrile function, antifebrile time, and comprehensive curative effect were observed. Results Body termperature of every syndrome group 2h, 3h, and 4h after medication was statistically different from before medication （P〈0.05 or P〈0.01）, and the effect starting-time of every syndrome group was not statistically different from each other （P〉0. 05）. Compared with the wind cold syndrome, the antifebrile time of wind heat and weifen and qifen diseased simultaneously syndromes was statistically different （P〈0.05）. The clinical cure rate of the syndrome wind attacking the exterior - cold and heat in complication and the syndrome weifen and qifen diseased simultaneously syndromes was the highest, statistically different from that of the syndrome wind cold and wind attacking the exterior -uncertain cold or heat （P〈0.05 or P〈0.01）. Conclusion Shanggan Granules is effective for all the above-mentioned five syndromes, of the viral upper respiratory tract infection fever patients, especially good for those with the syndromes of cold and heat in complication, weifen and qifen diseased simultaneously, and wind heat.

关 键 词：上感颗粒 病毒性上呼吸道感染 发热 中医证型 

分 类 号：R259[医药卫生—中西医结合]