活体肾移植供体中期安全性随访报告  

Medium term follow-up of donor safety in adult living donor kidney transplantation

作　　者：张磊[1,2] 潘光辉[2] 黄刚[1] 王长希[1] 费继光[1] 邱江[1] 李军[1] 陈国栋[1] 邓素雄[1] 傅茜[1] 陈立中[1] 

机构地区：[1]中山大学附属第一医院器官移植科,广州研究生510630 [2]广州医学院第二附属医院肾移植科

出　　处：《器官移植》2011年第4期190-193,共4页Organ Transplantation

基　　金：中山大学临床医学研究5010计划项目(2007003)

摘　　要：目的了解活体肾移植供体术后情况,评价供者术后中期生活质量和安全性。方法对87名活体肾移植供体进行中期随访,每次随访的内容包括填写调查问卷,了解并发症和肾功能情况。结果随访时间为术后12-65个月。供体中有10%认为捐肾对其婚姻有不利影响,供体仍感切口有轻度疼痛占59%,感觉体力下降占61%,因供肾而改变工种占26%,术后平均恢复工作的时间为102 d,经常感到抑郁的占2%;对捐肾不后悔的供体占99%。新发现高血压5例（6%）、糖耐量异常2例（2%）、镜下血尿4例（5%）、蛋白尿6例（7%）,另外发现血脂异常血症41例（47%）。供体术前、出院时和最后1次随访时血清肌酐分别为（65±14）μmol/L、（98±22）μmol/L、（88±17）μmol/L,肌酐清除率分别为（95±21）m l/m in、（65±16）m l/m in、（71±17）m l/m in,比较其差异均有统计学意义（均为P〈0.01）。结论供体术后中期生活质量较术前稍有下降,但绝大多数肾功能较为理想。Objective To observe the post-transplant conditions and evaluate midterm living quality and safety of living renal donors.Methods Eighty-seven donors of renal transplantation were followed up in medium term after transplantation.The follow-up content included questionnaire survey,complications and renal function.Results The period of follow-up was from 12 months to 65 months after transplantation.Nine cases（10 %） of donors considered that donation may adversely affect the marriage.Fifty-one cases（59 %） of donors felt a little pain in the incision.Fifty-three cases（61 %） claimed to experience a decrease in physical strength.Twenty-three（26 %） changed jobs because of the donation.The average time of returning to work was 106 d after transplantation.Two cases（2 %） suffered from depression frequently.Eight-six cases（99 %） never regretted of donation.Five cases（6 %）had newly diagnosed hypertension,2 cases（2 %） with abnormal glucose tolerance,4 cases（5 %）with hematuria,6 cases（7 %） with proteinuria and 41 cases（47 %） with dyslipidemia.The mean serum creatinine level of preoperation,postoperation and follow-up time were respectively（65±14） μmol/L,（98±22） μmol/L,（88±17） μmol/L.Their creatinine clearance rate was respectively（95±21） ml/min before donation,（65±16） ml/min at discharge,（71±17） ml/min at the latest follow-up.There was significant difference in these two renal function evaluation parameters（all in P0.01）.Conclusion Slight decline in living quality of donors was observed after nephrectomy while the renal function of living donors appears to be relatively excellent.

关 键 词：肾移植 活体供体 随访 肾功能 血清肌酐 内生肌酐清除率 

分 类 号：R733.7[医药卫生—肿瘤]