血一氧化氮和内皮素含量变化在大鼠急性脑血管痉挛中的作用  

Effects of nitric oxide and endothelin on acute cerebral vasospasm after subarachnoid hemrrhage in rats

作　　者：孙保亮[1] 夏作理[1] 葛宝林[1,2] 

机构地区：[1]泰山医学院附院微循环研究所,泰安271000 [2]青岛大学医学院病理生理教研室

出　　处：《中国病理生理杂志》1999年第11期1024-1026,共3页Chinese Journal of Pathophysiology

摘　　要：目的：探讨一氧化氮（ＮＯ） 、内皮素（ＥＴ） 在蛛网膜下腔出血（ＳＡＨ） 后急性脑血管痉挛（ＣＶＳ） 中的作用。方法：应用非开颅大鼠ＳＡＨ 模型，检测ＳＡＨ 前后基底动脉（ＢＡ） 管径改变，２４ ｈ 内大脑顶叶皮层局部脑血流量（ｒＣＢＦ） 、血中ＮＯ、ＥＴ 含量动态变化。结果：ＳＡＨ 后ＢＡ 管径明显缩小，在ＳＡＨ 后２４ ｈ 内ｒＣＢＦ 明显持续降低，血ＮＯ 含量自ＳＡＨ 后１ ｈ 开始持续低于术前值，而血ＥＴ 浓度则于ＳＡＨ 后立即高于术前值，并持续２４ ｈ 。结论：ＳＡＨ 后血ＮＯ 含量减低和ＥＴ浓度增加参与了急性ＣＶＳAIM:To investigate the possible roles which nitric oxide (NO), and endothelin (ET) play in the pathogenesis of acute stage of cerebral vasospasm (CVS) following subarachnoid hemorrhage (SAH). METHODS:Noncraniotomy models of SAH in Wistar rats were used. Animals were divided into sham-operated group and SAH group. Diameters of basilar artery (BA) in all animals were measured. Dynamic changes of cortical regional cerebral blood fow (rCBF) within 24 hours after operation were detected. Levels of NO, ET in intracranial blood at different time points within 24 hours after SAH were also determined in SAH group. RESULTS:Diameters of BA and rCBF were not changed in sham-operated group. Diameters of BA reduced and rCBF decreased obviously in SAH group. NO levels were significantly lower than those of preoperation while ET concentrations were significantly higher than those of preoperation after induction of SAH. CONCLUSION:Alterations of NO and ET in blood play important roles in the development of acute CVS after SAH.

关 键 词：蛛网膜下腔出血 一氧化氮 内皮素 脑血管痉挛 

分 类 号：R743.350.6[医药卫生—神经病学与精神病学] R362[医药卫生—临床医学]