强心苷抗肿瘤作用的研究进展  

Research Advances of Anti-tumor Effect of Cardiac Glycosides

作　　者：陈果[1] 徐庆[2] 

机构地区：[1]桂林医学院研究生学院,广西桂林541004 [2]桂林医学院药学院药理教研室,广西桂林541004

出　　处：《医学综述》2011年第13期2032-2034,共3页Medical Recapitulate

摘　　要：强心苷可以抑制肿瘤细胞增殖周期,结合Na+/K+-ATPase改变膜内外离子浓度并且激活一系列信号通路等引发凋亡。强心苷抑制细胞增殖,特异性结合Na+/K+-ATPase,引发细胞膜的Na+K+交换或者Na+/K+-ATPase作为配体激活一系列信号通路级联,引起细胞周期的改变,影响增殖与凋亡相关因子表达,介导肿瘤细胞凋亡,抑制肿瘤细胞增殖。强心苷可直接干预细胞周期的监测点,使肿瘤细胞生长停滞。现就近年来强心苷抗肿瘤作用的研究进展进行简要综述。Cardiac glycosides can inhibit the proliferation of cancer cells,bind Na＋,K＋-ATPase to change the ion concentrations inside and outside membrane and activate complex cell-signal transduction pathways,resulting in selective apoptosis.Cardiac glycosides inhibit the cell proliferation,specifically combine Na＋/K＋-ATPase,triggering Na＋,K＋ exchanging in the cell membranes or making Na＋/K＋-ATPase as the ligands activating a series of signaling pathways to cascade,causing the cell cycle changes,affecting the expression of proliferation and apoptosis related factors,mediating tumor cell apoptosis and inhibiting tumor cell proliferation.Cardiac glycosides can also intervene the monitoring point of the cell cycle,causing cell growth arrest.Here is to make a brief review focusing on recent findings of anticancer function of cardiac glycosides.

关 键 词：强心苷 Na+/K+-ATPase 肿瘤 凋亡 

分 类 号：R73[医药卫生—肿瘤]