腮腺主导管结扎后腺体的组织改变  

the Changes of Parotid Gland after Stensen's Duct was Ligated

作　　者：周竹云[1] 左金华[1] 吴淑华[2] 张景喜[1] 赵腾达[1] 

机构地区：[1]滨州医学院附属医院口腔颌面外科 [2]滨州医学院附属医院病理科,山东滨州256603

出　　处：《中外医疗》2011年第16期19-20,172,共3页China & Foreign Medical Treatment

基　　金：山东省教育厅科技计划资助(J08LG16);山东医药卫生科技计划(2007HW032)

摘　　要：目的观察腮腺主导管结扎后腺体组织的变化。方法用SD大鼠建立动物模型,将其右侧腮腺主导管结扎;定期获取标本,制备组织切片,HE染色、形态计量等方法,观察术后不同阶段腮腺组织中腺泡、导管及间质的形态变化及体积分数。结果腮腺主导管结扎后,腺体组织开始萎缩,其中腺泡体积分数逐渐减少,至30d时已完全消失;间质、导管及体积分数增加;各时间组中各组织成分的体积分数与对照组均有显著差异(P<0.05);萎缩后的腺体最终由扩张及增生的导管、间质(主要含纤维结缔组织)构成。结论腮腺主导管结扎后可促使腺体发生萎缩,失去分泌功能从而避免腮腺区域术后涎瘘等并发症的发生。Objective This study investigated the changes of the Parotid gland tissue after stensen＇s duct ligation.Methods We build the animal model use the SD rat.The experimental group rat＇s Stensen＇s duct（right side）was exposed and ligated at each time point（1、6、12、20、30d）,than used HE stain and morphometry investigatd the morphological and volume fraction changes of acini cells,myoepithelia cells,duct（Intercalated duct and striated duct）and interstitial substance.Results The parotid gland tissue of experimental group begins to atrophy after stensen＇s duct ligation.Through the morphological we can know that acinar volume fraction gradual decline and disappeared at30d.Interstitial substance and duct increase in volume fraction.At30d,the atrophy of the parotid gland was composed of interstitial substance,duct,and myoepithelial cells.Conclusion The parotid gland tissue begins to atrophy after stensen＇s duct ligation.We can avoide salivary fistula by ligate the stensen＇s duct in the surgery of parotid region.

关 键 词：腮腺导管 结扎 萎缩 腺泡 形态计量 

分 类 号：R78[医药卫生—口腔医学]