三维适形放疗肺癌脑转移瘤32例疗效分析  

The Efficacy of 32 Case of Three-dimensional Conformal Radiotherapy of Brain Metastases of Lung Cancer

作　　者：邢爱民[1] 赵静[1] 邢浩[1] 张念波[1] XING Ai-min,ZHAO Jing,XING Hao,ZHANG Nian-bo（tumor branch 152nd Central hospital of People＇s Liberation Army,Pingdingshan 467000,China）

机构地区：[1]解放军第152中心医院肿瘤科,河南平顶山467000

出　　处：《医学信息》2011年第13期4171-4172,共2页Journal of Medical Information

摘　　要：目的探讨肺癌脑转移瘤患者采用三维适形放射治疗的疗效和毒副作用。方法对32例肺癌脑转移瘤患者先行第一计划分别设3～4野非共面三维适形照射,2GY/次,5次/周,常规放疗总剂量30GY～35GY;第二计划针对病灶勾画靶区,晶体、脑干等重要器官剂量严格控制在安全范围内,采用4～6个非共面野三维适形照射,肿瘤分割剂量为2.5GY～3GY/次,5次/周,缩野总剂量15GY～23GY。结果 32例患者中完全缓解（CR）14例占43.8%,部分缓解（PR）12例占37.5%,无效（NC）者6例占18.8%。总缓解率（CR＋PR）为81.3%。在随访半年内有8例患者死亡,其中3例死于脑转移瘤的复发,5例死于颅外肿瘤的进展。结论肺癌脑转移瘤患者给予三维适形放射治疗,能明显地提高肿瘤局部控制率,改善生活质量,延长生存期。Objective To investigate patients with brain metastases of lung cancer using three-dimensional conformal radiation therapy efficacy and side effects.Methods 32 cases of lung cancer patients with brain metastases were first set up the first plans 3 to 4 field noncoplanar three-dimensional conformal radiation,2GY / times,5 times / week,total dose of conventional radiotherapy 30GY~35GY;second plan outlined for the lesions target,crystal,brain stem and other vital organs in a safe dose range of strictly controlled,with 4 to 6 non-coplanar conformal radiation field,tumor segmentation dose 2.5GY~3GY / times,5 times / week,reduced field total dose of 15GY~23GY.Results 32 patients complete remission（CR）14 cases accounting for 43.8%,partial response（PR） 12 cases accounting for 37.5%,invalid（NC）,6 cases accounted for 18.8%.The overall response rate（CR＋PR）was 81.3%.Within six months of follow-up 8 patients died,3 died of recurrence of brain metastases,5 patients died of extracranial tumor progression.Conclusion lung cancer with brain metastases were treated with three-dimensional conformal radiation therapy,can significantly improve local tumor control rate and improve the quality of life and prolong survival.

关 键 词：肺癌 脑转移瘤 三维适形放疗 疗效 

分 类 号：R739.410.5[医药卫生—肿瘤;医药卫生—临床医学]