适形调强放疗联合化疗治疗非小细胞肺癌36例  

Intensity Modulated Radiation Therapy Combined with Chemotherapy in the Treatment of 36 Cases of Non-small Cell Lung Cancer

作　　者：赵静[1] 邢爱民[1] 张念波[1] 邢浩[1] ZHAO Jing,XING Ai-min,ZHANG Nian-bo,XING Hao（tumor branch 152nd Central hospital of People＇s Liberation Army,Pingdingshan 467000,China）

机构地区：[1]解放军第152中心医院肿瘤科,河南平顶山467000

出　　处：《医学信息》2011年第13期4173-4174,共2页Journal of Medical Information

摘　　要：目的评价三维适形调强放疗联合化疗在治疗中、晚期非小细胞肺癌（NSCLC）的作用。方法 36例中、晚期非小细胞肺癌采用随机分两组治疗。A组采用常规放疗加化疗,共18例,放疗量60～66Gy;B组采用三维适形调强放疗加化疗,共18例,放疗量70～76Gy。两组均采用铂类联合诺维苯方案化疗1周期后放疗,放疗结束后再化疗3～5个周期。结果 A组有效率（CR＋PR）43.3%,B组有效率83.3%。经统计学处理,A组与B组比较,χ2=5.54,P=0.0186。A组1年生存率38.9%（7/18）,B组为88.89%（16/18）。两组之间差异有统计学意义。结论随着放疗剂量增加,疗效增高,三维适形调强放疗组有效率比常规放疗组高,三维适形调强组1年生存率比常规放疗高,统计学差异有显著意义。而放射性食管炎并没有增加,急性放射性肺炎调强组反而下降。Objective To evaluate the three-dimensional conformal intensity modulated radiation therapy combined with chemotherapy in the treatment of advanced non-small cell lung cancer（NSCLC） role.Methods 36 patients with advanced non-small cell lung cancer treatment were randomly divided into 2 groups.A group of conventional radiotherapy plus chemotherapy,a total of 18 cases,radiotherapy volume 60~66Gy,B group group by three-dimensional intensity modulated radiation therapy plus chemotherapy,a total of 18 cases,radiotherapy volume 70~76Gy.2 groups were combined with platinum chemotherapy Dirk benzene after 1 cycle of radiotherapy,radiotherapy and chemotherapy after the end of 3 to 5 cycles.Results A set of effective（CR＋PR） 43.3%,B 83.3% efficiency;the statistical analysis： A group and B group χ2=5.54,P=0.0186.Year survival rate： A group of 1-year survival 38.9%（7/18）,B group and 88.89%（16/18）.Differences between the 2 groups was significant.Conclusion The results showed increased efficacy with increased radiation dose,three-dimensional conformal intensity modulated radiation therapy group was higher than conventional radiotherapy,intensity modulated three-dimensional conformal group 1 year survival rate higher than conventional radiotherapy,the difference was statistically significant.And no increase in radiation esophagitis,acute radiation pneumonitis IMRT group decreased.

关 键 词：非小细胞肺癌 适形调强放疗 化疗 

分 类 号：R730.55[医药卫生—肿瘤;医药卫生—临床医学]