Kiss-1及MVD在非小细胞肺癌中检测的临床意义及其相关性研究  

Detections of Kiss-1 and MVD in Non Small Cell Lung Cancer and Their Clinical Significance

作　　者：赵丽敏[1] 薄永青 郭莉[1] 赵玲[1] 赵腾[1] 王晓红 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,黑龙江哈尔滨150081 [2]日照市东港区涛雒镇医院,山东日照276805

出　　处：《现代生物医学进展》2011年第14期2677-2680,共4页Progress in Modern Biomedicine

摘　　要：目的:测定NSCLC组织中kiss-1基因表达、MVD分布,探讨其临床意义及其相关性。方法:应用免疫组化SP法检测56例NSCLC组织中Kiss-1表达及MVD分布情况,分析其与NSCLC的临床病理参数的关系及其相关性。结果:kiss-1在NSCLC表达低于对照组(P<0.05),MVD在NSCLC分布明显高于对照组(P<0.05)。Kiss-1与NSCLC的临床分期、淋巴结转移、肿瘤大小有关(P<0.05)。MVD与NSCLC分化程度、临床分期及淋巴结转移、肿瘤大小有关(P<0.05).Kiss-1阳性组MVD分布明显低于Kiss-1阴性表达组,二者呈负相关(P<0.05,r=-0.363)。结论:Kiss-1及MVD在非小细胞肺癌发生、发展中发挥重要作用,二者存在相关性,联合检测可帮助预测NSCLC的侵袭、转移,判断预后。Objective： To detect the expressions of kiss-1 and distribution of MVD in non small cell lung cancer,to investigate their clinical significance and associativity.Methods： The expressions of kiss-1 and distribution of MVD were detected in 56 non small cell lung cancer by immunohistochemical SP method.Results： In non small cell lung cancer,express of kiss-1 is lower than control group（P0.05）.Distribution of MVD is super than control group（P0.05）.Kiss-1 is concerned with clinical stageand,metastasis of lymph nodes in NSCLC P0.05）,and MVD is concerned with differentiated level and clinical stageand and metastasis of lymph nodes in NSCLC（P0.05）.Distribution of MVD in the expression positive rate of kiss-1 is higher than that in the expression negative rate of kiss-1 in the tissue of NSCLC,they have negative correlation（P0.05,r=-0.363）.Conclusions： Kiss-1 and MVD have important role in occurrence and progress of NCSCL.We can predict invasion,metastasis and prognosis of NSCLC by uniting detection kiss-1 and MVD.

关 键 词：KISS-1 MVD 非小细胞肺癌 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]