与卵巢癌转移有关的microRNA研究进展  

Research of microRNA Related to Metastasis of Ovarian Cancer

作　　者：李泽夏[1] 刘海玲[1] 吕辉[1] 吴晓英[1] 

机构地区：[1]中南大学湘雅医学院医学超微结构学教研室,湖南长沙410008

出　　处：《现代生物医学进展》2011年第14期2793-2796,共4页Progress in Modern Biomedicine

摘　　要：卵巢癌是女性生殖系统三大恶性肿瘤之一,其致死率居于各类妇科肿瘤之首,是严重影响妇女生命的重要疾患,卵巢癌的转移则是造成病人死亡的重要因素。近年来随着microRNA(又称miRNA或微RNA)作为一种小分子非编码RNA被发现,证实miRNA的作用与各类肿瘤有着重要的联系,这些肿瘤包括乳腺癌、食管癌、胰癌、口腔癌等。近几年的研究表明,miRNA可以影响卵巢癌的发生与发展,并与其转移也存在着紧密的关系。与卵巢癌转移有关的miRNA作用机制的揭示,将会为转移性卵巢癌的诊断及治疗提供新的途径。本综述在通过检索近年来最新文献的基础上,对于卵巢癌的转移机理进行了详尽的分析,并对miRNA在卵巢癌转移中的重要研究予以了详细的阐述。As one of the three major malignant tumors concerning the female reproductive system,ovarian cancer＇s lethality is the leading cause of death from gynecologic cancers.It severely affects women＇s lives.The metastasis of Ovarian cancer is an important factor in causing deaths.MicroRNA＇s（miRNA） are a recently discovered class of Small molecule and noncoding RNA＇s.There is a Sig-nificant relationship between microRNAs and various types of cancer,these tumors include breast cancer,esophageal cancer,pancreatic cancer,oral cancer,etc.In recent years,some studies have shown that miRNA could have a great influence on the occurrence and devel-opment of ovarian cancer,and also on the metastasis of Ovarian cancer.If miRNA mechanism was revealed to be related to the metas-tasis of ovarian cancer,it would provide a new approach to the diagnosis and treatment of metastatic ovarian cancer.Based on the latest literature,this review is a detailed analysis on the metastatic mechanism of ovarian cancer and the role of miRNA within it.

关 键 词：卵巢癌 肿瘤转移 MICRORNAS 

分 类 号：R737.31[医药卫生—肿瘤]