中性粘多糖对脑缺血再灌注沙土鼠红细胞β-内啡呔和免疫粘附功能的影响  

The study on the effect of NM upon RBC-β-EP and RCIA during cerebral ischemia-reperfusion in gerbil

作　　者：丁素菊[1] 郑惠民[1] 候晓军 郭峰[2] 王成海 

机构地区：[1]第二军医大学长海医院神经内科,上海200433 [2]第二军医大学长海医院免疫室,上海200433 [3]第二军医大学神经生物教研室,上海200433

出　　处：《深圳中西医结合杂志》1999年第5期18-19,共2页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：上海市自然科学资金!BB01076

摘　　要：目的观察中性粘多糖（neutralmucopolysaccharideNM）对缺血再灌注沙土鼠红细胞β-内啡吹（β-endorphinβ－EP）和免疫粘附功能（redcellimmuneadherenceRCIA）的影响；进一步探讨NM对防治缺血再灌注脑组织损伤的机理。方法采用蒙古种沙土鼠缺血再灌注模型分别测定红细胞β-EP（RBC－β-EP）含量以及RCIA功能，观察两者相互关系。结果提前喂服NM在沙土鼠再灌注时RBC－β-EP含量明显降低，RCIM能力增强；随红细胞β-EP含量下降，RCIA能力所有加强。结论NM在沙土鼠脑缺血再灌注时具有阻断RBC－β-EP的过度产生，有助于改善红细胞免疫功能的作用。Objcetive To ivestigate the effect of NM upon RBC -β- EP and RCIA during cerebral ischemia - reperfusion in gerbil and to Probe into the Protective effect of NM upon brain damage following cercbral ischemia and reperfosion. Method RCIA and RBC - β- EP were both measured in models of cerebeal ischemia and reperfution of Mongolian gerbil. Results RBC - β- EP decreases markly while RCIA strengthens during cerebral ischemia and reperfusion in gerbil pretreated with NM. Chnclusion RBC - β- EP promted the function of RCIA, excessive amounts of RBC -β- EP inhibited the function of RCIA. The suggests that NM can block RBC - β- EP production. It contributes to improve the function of RCIA in cerebral ishdria reperfusion.[

关 键 词：中性粘多糖 红细胞免疫 β内啡呔 脑缺血 

分 类 号：R743.310.2[医药卫生—神经病学与精神病学]