肿瘤转移抑制基因nm 23-H 1 mRNA在人卵巢癌中的表达  

Expression of tumor metastasis suppressor gene nm23 H1 mRNA in human ovarian carcinomas

作　　者：周晓宁[1] 陈晓东[2] 王昭梅[1] 沙金燕[1] 崔英[1] 顾青[1] 姜海燕[1] 

机构地区：[1]第二军医大学长海医院妇产科,上海200433 [2]广州军区广州总医院病理科

出　　处：《第二军医大学学报》1999年第10期743-745,共3页Academic Journal of Second Military Medical University

摘　　要：目的：通过检测人卵巢癌标本中肿瘤转移抑制基因ｎｍ ２３－Ｈ１ ｍ ＲＮＡ 的表达，了解其临床意义及其与预后的关系。方法：应用原位杂交技术检测４３例人卵巢癌标本中ｎｍ ２３－Ｈ１ ｍ ＲＮＡ 的表达水平。结果：ｎｍ ２３－Ｈ１ ｍ ＲＮＡ 表达水平与卵巢癌的病理组织学类型无关（Ｐ＞ ０．０５）；与患者术时有淋巴结或大网膜转移呈负相关（Ｐ＜ ０．０５）；且转移灶的阳性表达率低于原发灶（Ｐ＜ ０．０５）。结论：ｎｍ ２３－Ｈ１基因在人卵巢癌的扩散和转移过程中可能发挥着抑制作用，它在卵巢癌组织中的表达水平具有重要的临床意义。Objective: To detect the expression of tumor metastasis suppressor gene nm23 H1 mRNA in human ovarian carcinomas, and to evaluate its clinic value as well as its relationship with prognosis. Methods: The expression of nm23 H1 mRNA was detected in 43 cases of human ovarian carcinomas by means of in situ hybridization. Results: The expression of nm23 H1 mRNA did not statistically correlated with histologic types of ovarian carcinomas ( P >0.05); there was an inverse relationship between nm23 H1 mRNA level and those cases with metastasis foci both in lymph nodes and in the great omentum( P <0 05); positive rate of nm23 H1 mRNA was higher in primary than in metastatic foci( P <0.05). Conclusions: nm23 H1 gene may play an important role in suppressing metastasis of ovarian carcinomas. The expression of nm23 H1 gene in ovarian cancer tissues may serve as one of assessable factors for prognosis in ovarian carcinoma.

关 键 词：卵巢肿瘤 肿瘤转移 抑制基因 原位杂交 MRNA 

分 类 号：R737.310.2[医药卫生—肿瘤] R73－37[医药卫生—临床医学]