中国多发性硬化患者肿瘤坏死因子β基因多态性的Meta分析  

Correlation of the tumor necrosis factor beta gene polymorphism and risk of multiple sclerosis in Chinese population: a meta-analysis

作　　者：孙庆利[1] 樊东升[1] 孙阿萍[1] 寿延红[1] 傅瑜[1] 李小刚[1] 谢汝萍[1] 

机构地区：[1]北京大学第三医院神经科,100191

出　　处：《中国神经免疫学和神经病学杂志》2011年第4期250-252,260,共4页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的探讨肿瘤坏死因子β（TNF—β）基因多态性与中国多发性硬化（MS）患者遗传易感性能关系。方法通过PubMed、Elseiver、Ovid、中国期刊全文数据库（CNKI）和万方数据库，检索有关TNF—β基因多态性与中国MS患者的病例对照研究文献，并采用RVEMAN4．3统计软件对其结果进行分析。结果共纳入5篇以中国人群为研究对象的MS病例对照研究文献。各研究的基因型和等位基因频数结果未见明显发表偏倚。5项研究合并后，GG／（GA＋AA）、AA／（GG＋GA）和GA／（GG4-AA）合并的OR值分别为1．63（95％CI为0．78～3．43）、0．85（95％CI为0．41～1．76）和0．81（95％CI为0．60～1．10）。等位基因频数G／A的OR=1．21（95％CI为0．74～1．99，P=0．45）。结论TNF-β基因多态性与中国Ms患者的遗传易感性无相关性。Objective To investigate the association of the potymorphism of the tumor necrosis; factor beta gene and multiple sclerosis in Chinese population. Methods A computer-based online search was conducted in PubMed, Elseiver, Ovid Database, China National Knowledge Infrastructure, and Wanfang Database. Casecontrol studies addressing the association of the polymorphism of the tumor necrosis factor beta gene and raultiple sclerosis in Chinese population were included in this review. The Meta-analysis software, REVMAN 4.3, was applied for investigating heterogeneity, pooled OR value and 95% CI among individual studies. Results Five case-control studies were included after screening and application of inclusion and exclusion criteria. Pooled data results showed the OR value of GG/ （GA＋AA）, AA/ （GG＋GA） and GA/ （GG＋AA） were 1.63 （95% CI： 0.78-3.43 ）, 0.85 （95% CI： 0.41-1.76）, 0.81 （95G CI： 0.60-1.10 ）, respectively. The allele frequencies OR value of G/A was 1.21 （ 95% CI： 0. 74-1.99）. Conclusions The results suggested that the polymorphism of the tumor necrosis factor beta gene was not significantly associated with susceptibility of multiple sclerosis in Chinese population.

关 键 词：肿瘤坏死因子Β 多发性硬化 多态性 荟萃分析 

分 类 号：R744.51[医药卫生—神经病学与精神病学]