代谢因素与糖尿病周围神经病的关系  

Relationship between Metabolic Factors and Diabetic Peripheral Neuropathy in Patients with Diabetic

作　　者：祝滨[1] 钟琪[1] 徐明然 黄流清[2] 

机构地区：[1]上海市黄浦区中心医院神经内科,上海200002 [2]第二军医大学附属长征医院神经内科,上海200003

出　　处：《中国临床医学》2011年第3期360-361,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:研究糖尿病各种代谢因素和糖尿病周围神经病的关系。方法:将182例2型糖尿病患者根据肌电图和神经传导速度测定的结果分为糖尿病周围神经病大纤维病变(diabetic peripheral neuropathy,DPN)组(66例)和无糖尿病周围神经病大纤维病变组(116例)。分别记录2组患者性别、年龄、糖尿病病程,测量体质量、身高、血压、空腹血糖、餐后2h血糖及血糖化血红蛋白、三酰甘油和高密度脂蛋白胆固醇等指标。结果:糖尿病患者年龄越大(P=0.014),病程越长(P=0.000),合并高血压(P=0.003)和体质量指数(BMI)异常(P=0.033),餐后2h血糖(P=0.046)以及糖化血红蛋白(P=0.008)控制不佳,容易发生糖尿病周围神经病大纤维病变,其中年龄、糖尿病病程、收缩压、血糖化血红蛋白均和下肢腓肠神经感觉波幅呈负相关。Logistic回归分析显示,患者年龄、高血压情况以及餐后2h血糖为糖尿病周围神经病大纤维病变的主要影响因素。结论:糖尿病发病年龄、病程以及血压、BMI和血糖控制水平与糖尿病周围神经病大纤维病变的发生密切相关。Objective：To analyze the correlation between metabolic factors and diabetic large fiber neuropathy.Methods：We divided 182 diabetic mellitus type II patients according to the results of nerve conduction velocity into two groups,with diabetic peripheral neuropathy（66 patients） and without diabetic peripheral neuropathy（116 patients）.We recorded their gender,age,duration of diabetic mellitus,body weight,height,blood pressure,fasting blood glucose,2h postprandial blood glucose,glycosylated hemoglobin,triglyride and high density lipoprotein etc respectively.Results：we found the age（P=0.014）,diabetic mellitus duration（P=0.001）,with hypertension（P=0.003） and abnormal body mass index（BMI）（P=0.033）,2h postprandial blood glucose（P=0.046）,glycosylated hemoglobin（P=0.008） are related to the morbidity of diabetic large fiber neuropathy.Among these factors,the age,duration of diabetic mellitus,systolic blood pressure,glycosylated hemoglobin are negatively correlated with the sural nerve sensory amplitude.In the logistic regression analysis,we found age,with hypertension and high 2h postprandial blood glucose are the main factors.Conclusions：The age,duration of diabetic mellitus,blood pressure,BMI and blood glucose level are closely related to the incidence of diabetic large fiber neuropathy.

关 键 词：糖尿病周围神经病 代谢因素 

分 类 号：R745.4[医药卫生—神经病学与精神病学]