N-邻甲氧基苯甲酰基-N'-芳酰氨基硫脲的合成与抑菌活性研究  

Syntheses and Antibacterial Activities of N-o-MethoxybenzoylN'-Substituted Benzoyl Thiosemicarbazides

作　　者：柳文敏 陈长中 牛秋红[2] 陈曼 

机构地区：[1]化学与制药工程学院 [2]生物与生命科学学院南阳师范学院,南阳473061

出　　处：《化学通报》2011年第7期665-668,共4页Chemistry

基　　金：河南省科技厅科技攻关项目(092102310216)资助

摘　　要：由邻甲氧基苯甲酰氯与硫氰酸钾反应生成邻甲氧基苯甲酰基异硫氰酸酯,再与芳酰肼进行加成反应,合成了8种邻甲氧基苯甲酰基芳酰氨基硫脲衍生物,其结构经元素分析、红外光谱和1H NMR确证。初步的生物活性测试结果表明,该类化合物对枯草杆菌有抑制作用,而对大肠杆菌无明显的抑制作用。Eight N-o-methoxybenzoyl-N＇-substituted benzoyl thiosemicarbazides were synthesized by addition reaction of aroyl hydrazines with o-methoxybenzoyl isothiocyanates,which was obtained via the reaction of o-methoxybenzoyl chloride with potassium isothiocyanate.The structures of as-synthesized thiosemicarbazides were characterized by 1H NMR,IR and elemental analysis.The preliminary tests of their biological activities indicated that they have antibacterial activity against B.subtilis,but have no obvious inhibition activity against E.coli.

关 键 词：邻甲氧基苯甲酰氯 酰氨基硫脲 芳基酰肼 合成 抑菌活性 

分 类 号：O621.3[理学—有机化学]