Wnt signaling through T-cell factor phosphorylation  

作　　者：Sergei Y Sokol 

机构地区：[1]Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA

出　　处：《Cell Research》2011年第7期1002-1012,共11页细胞研究（英文版）

摘　　要：Embryonic signaling pathways often lead to a switch from default repression to transcriptional activation of target genes. A major consequence of Wnt signaling is stabilization of β-catenin, which associates with T-cell factors （TCFs） and ＇converts＇ them from repressors into transcriptional activators. The molecular mechanisms responsible for this conversion remain poorly understood. Several studies have reported on the regulation of TCF by phosphorylation, yet its physiological significance has been unclear： in some cases it appears to promote target gene activation, in others Wnt-dependent transcription is inhibited. This review focuses on recent progress in the understanding of context-dependent post-translational regulation of TCF function by Wnt signaling.

关 键 词：TCF Wnt PHOSPHORYLATION β-catenin Homeodomain-interacting protein kinase Nemo-like kinase 

分 类 号：Q257[生物学—细胞生物学] S852.4[农业科学—基础兽医学]