Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy  

作　　者：Xiaofeng Yang Yifeng Xu Naiwu Lu Yibin Zhang Hongmei Wang Xin Lu Jiping Cui JinxuZhou Hong Shan Yanxiang Wu Xinping Liu 

机构地区：[1]Cell Treatment Center, Chinese PLA 463 Hospital, Shenyang 110042, Liaoning Province, China

出　　处：《Neural Regeneration Research》2011年第10期785-789,共5页中国神经再生研究（英文版）

基　　金：a grant by Key Projects of Liaoning Province, No. 2008225009

摘　　要：Due to their relative abundance,stable biological properties and excellent reproductive activity,umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy,which is a muscular atrophy disease.Three patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion,in combination with multi-point intramuscular injection.They were followed up for 12 months after cell transplantation.Results showed that clinical symptoms significantly improved,daily living activity and muscle strength were enhanced,the sero-enzyme,electromyogram,and MRI scans showed improvement,and dystrophin was expressed in the muscle cell membrane.Hematoxylin-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged,fibrous degeneration was alleviated,and fat infiltration was improved.These pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy.Due to their relative abundance,stable biological properties and excellent reproductive activity,umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy,which is a muscular atrophy disease.Three patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion,in combination with multi-point intramuscular injection.They were followed up for 12 months after cell transplantation.Results showed that clinical symptoms significantly improved,daily living activity and muscle strength were enhanced,the sero-enzyme,electromyogram,and MRI scans showed improvement,and dystrophin was expressed in the muscle cell membrane.Hematoxylin-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged,fibrous degeneration was alleviated,and fat infiltration was improved.These pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy.

关 键 词：umbilical cord mesenchymal stem cells Duchenne muscular dystrophy case report DYSTROPHIN muscular force activities of daily living 

分 类 号：S944.45[农业科学—水产养殖] S943.232[农业科学—水产科学]